{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:33:58Z","timestamp":1791398038979,"version":"4.3.3"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,14]],"date-time":"2019-04-14T00:00:00Z","timestamp":1555200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Catheter\u2010based endobiliary radiofrequency ablation (RFA) is an endoscopic local treatment for patients with malignant biliary stricture (MBS). However, excessive heating of the bile duct by the current RFA system can induce serious complications. Recently, a new RFA system with automatic temperature control was developed. In the present study, we examined the safety of the new RFA system in patients undergoing endobiliary RFA for extrahepatic MBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, multicenter study enrolled patients with unresectable or inoperable extrahepatic (&gt;\u00a02\u00a0cm from the hilum) MBS. Endobiliary RFA was performed using a newly developed RFA catheter (ELRA\u2122, STARmed, Goyang, Korea) at a setting of 7 or 10\u00a0W for 120\u00a0s and with a target temperature of 80\u00b0C. A self\u2010expandable metallic stent was inserted after endobiliary RFA. The rate of procedure\u2010related adverse events was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 30 patients were enrolled in this study. Cholangiocarcinoma was diagnosed in 19 patients, pancreatic cancer was found in 9, and gallbladder cancers were recorded in 2. The mean stricture length was 22.1\u00a0\u00b1\u00a06.6\u00a0mm. Post\u2010procedural adverse events occurred in three patients (10.0%; 2 mild pancreatitis and 1 cholangitis) without hemobilia and bile duct perforation. The pancreatitis and cholangitis resolved with conservative treatment. The cumulative duration of stent patency and survival were 236 and 383\u00a0days, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Automatic temperature\u2010controlled endobiliary RFA using a newly developed catheter was safely applied in patents with extrahepatic MBS. Further prospective studies are needed to confirm the efficacy of endobiliary RFA for MBS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14657","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T21:06:47Z","timestamp":1552424807000},"page":"1454-1459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["The safety of newly developed automatic temperature\u2010controlled endobiliary radiofrequency ablation system for malignant biliary strictures: A prospective multicenter study"],"prefix":"10.1111","volume":"34","author":[{"given":"Yun Nah","family":"Lee","sequence":"first","affiliation":[{"name":"Digestive Disease Center and Research Institute, Department of Internal Medicine Soonchunhyang University School of Medicine  Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok","family":"Jeong","sequence":"additional","affiliation":[{"name":"Digestive Disease Center, 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