{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:28:12Z","timestamp":1791041292590,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Gastroesophageal reflux disease (GERD) is a common disease caused by reflux of gastric contents to the esophagus. Proton\u2010pump inhibitors (PPIs) are recommended as a first\u2010line therapy to treat GERD. Recently, a new potassium\u2010competitive acid blocker, vonoprazan, was launched in Japan. We aimed to evaluate the comparative efficacy of vonoprazan and other PPIs in healing GERD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used MEDLINE and the Cochrane Central Register of Controlled Trials to search the literature. Double\u2010blind randomized controlled trials for PPIs and\/or vonoprazan that were published in English or Japanese and assessed healing effects in adult GERD patients were included. To estimate the comparative efficacy of treatments, we performed a Bayesian network meta\u2010analysis to assess the consistency assumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 4001 articles identified in the database, 42 studies were eligible. One study was hand\u2010searched and added to the analysis. For the main analysis of healing effects at 8\u00a0weeks, odds ratios (ORs) of vonoprazan (20\u00a0mg daily) to esomeprazole (20\u00a0mg), rabeprazole (20\u00a0mg), lansoprazole (30\u00a0mg), and omeprazole (20\u00a0mg) were 2.29 (95% credible interval, 0.79\u20137.06), 3.94 (1.15\u201314.03), 2.40 (0.90\u20136.77), and 2.71 (0.98\u20137.90), respectively. Subgroup analysis for patients with severe esophagitis at baseline showed significantly higher ORs for vonoprazan <jats:italic>versus<\/jats:italic> most of the comparator PPIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This analysis shows that the GERD healing effect of vonoprazan is higher than that of rabeprazole (20\u00a0mg) but not higher than other PPIs. Subgroup analysis indicated that vonoprazan is more effective than most PPIs for patients with severe erosive esophagitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14664","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T05:23:42Z","timestamp":1552973022000},"page":"1316-1328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Vonoprazan <i>versus<\/i> proton\u2010pump inhibitors for healing gastroesophageal reflux disease: A systematic review"],"prefix":"10.1111","volume":"34","author":[{"given":"Hirota","family":"Miyazaki","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical College  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ataru","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Health Economics and Outcomes Research, Graduate School of Pharmaceutical Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical College  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lida","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Health Economics and Outcomes Research, Graduate School of Pharmaceutical Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Uda","sequence":"additional","affiliation":[{"name":"Japan Medical Affairs Takeda Pharmaceutical Company Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisato","family":"Deguchi","sequence":"additional","affiliation":[{"name":"Japan Medical Affairs Takeda Pharmaceutical Company Ltd  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical College  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Tango","sequence":"additional","affiliation":[{"name":"Director's Office Center for Medical Statistics  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(02)00040-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200321110-00002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X38240"},{"key":"e_1_2_6_5_1","first-page":"577","article-title":"Critical issues in the management of gastroesophageal reflux disease","volume":"7","author":"Freston JW","year":"1995","journal-title":"Eur. 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