{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:25:28Z","timestamp":1783103128073,"version":"3.54.6"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["12130671"],"award-info":[{"award-number":["12130671"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Comorbid generalized anxiety disorder and irritable bowel syndrome are common and therapeutically challenging. We aimed to assess the effectiveness of electroacupuncture in relieving anxiety and bowel symptoms in Chinese adults with this form of comorbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a single\u2010blind randomized sham\u2010controlled trial, subjects with comorbid generalized anxiety disorder and irritable bowel syndrome were randomly assigned to receive 10 weekly sessions of electroacupuncture or sham electroacupuncture. Patients were assessed at baseline, immediately after intervention and at 6\u2010week follow\u2010up. Primary outcome was anxiety (7\u2010item Patient Health Questionnaire section for anxiety). Secondary outcomes included bowel symptoms (bowel symptoms questionnaire), depressive symptoms (9\u2010item Patient Health Questionnaire), somatic symptoms (15\u2010item Patient Health Questionnaire), and health\u2010related quality of life (EuroQol\u20105 Dimensions).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty subjects, 40 in each arm, were randomized. All but two in the sham group completed 10 weekly sessions. There was no significant difference in the proportion of patients experiencing significant (\u2265\u00a050%) reduction of anxiety symptoms between the two groups immediately after intervention (32.4% <jats:italic>vs<\/jats:italic> 21.6%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.06) and at 6\u2010week follow\u2010up (25.7% in electroacupuncture <jats:italic>vs<\/jats:italic> 27% in sham, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.65). Anxiety, depressive symptom, and bowel symptom severity did not differ significantly between electroacupuncture and sham groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings failed to support the effectiveness of electroacupuncture for comorbid generalized anxiety disorder and irritable bowel syndrome. Further studies are needed to identify effective acupuncture treatment protocols for such comorbidity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14667","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T04:13:56Z","timestamp":1553055236000},"page":"1736-1742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Noneffectiveness of electroacupuncture for comorbid generalized anxiety disorder and irritable bowel syndrome"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1627-6434","authenticated-orcid":false,"given":"Arthur Dun\u2010Ping","family":"Mak","sequence":"first","affiliation":[{"name":"Department of Psychiatry The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5947-4492","authenticated-orcid":false,"given":"Vincent Chi Ho","family":"Chung","sequence":"additional","affiliation":[{"name":"Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suet Ying","family":"Yuen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee Kit","family":"Tse","sequence":"additional","affiliation":[{"name":"Institute of Integrative Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Yeung Shan","family":"Wong","sequence":"additional","affiliation":[{"name":"Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Ju","sequence":"additional","affiliation":[{"name":"Institute of Integrative Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheung Sheung","family":"Hung","sequence":"additional","affiliation":[{"name":"Institute of Integrative Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Chun","family":"Leung","sequence":"additional","affiliation":[{"name":"Institute of Integrative Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce Hoi Sze","family":"You","sequence":"additional","affiliation":[{"name":"Centre for Pharmacoeconomics Research The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashid","family":"Lui","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunny Hei","family":"Wong","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen Ngo Wang","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7252-970X","authenticated-orcid":false,"given":"Linda Chiu Wa","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sing","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin Che Yuen","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04074.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07296.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2009.06.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12036"},{"key":"e_1_2_6_6_1","article-title":"Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome","author":"Ruepert L","journal-title":"Cochrane Database Syst. 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