{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T14:55:55Z","timestamp":1775660155721,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Oral 5\u2010aminosalicylic acid (5\u2010ASA) is recommended for the therapy of mild to moderate intestinal Beh\u00e7et's disease (BD). However, the induction remission efficacy and endoscopic outcomes of 5\u2010ASA are unknown. We investigated remission induction at 8\u00a0weeks, endoscopic outcomes until 52\u00a0weeks, and event\u2010free survival at 52\u00a0weeks in patients with intestinal BD treated with 5\u2010ASA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010one patients with intestinal BD were treated with oral 5\u2010ASA. Clinical remission was evaluated with the Crohn's disease activity index (CDAI). The endoscopic response was evaluated using the modified global gastrointestinal endoscopic assessment scores. Rescue therapy\u2010free survival and surgery\u2010free survival at 52\u00a0weeks were estimated, and predictive factors for a clinical response at weeks 8 and 52 were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven patients (17%) withdrew 5\u2010ASA early (\u2264\u00a08\u00a0weeks) because of adverse events. At week 8, clinical efficacy could be accurately evaluated in 28 patients, and the response and remission rates were 61% and 57%, respectively, using the CDAI. Endoscopic evaluation was achieved in 17 patients up to 52\u00a0weeks, and the endoscopic response and remission rates were 71% and 35%, respectively. The probabilities of rescue therapy\u2010free survival and surgery\u2010free survival were 73% and 100%, respectively, at 52\u00a0weeks in all 41 patients. The predictive factors for therapeutic effectiveness at week 8 were a higher baseline C\u2010reactive protein level and CDAI, but they were negative predictive factors for a 52\u2010week response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>5\u2010ASA is effective for clinical and endoscopic induction and maintaining a response in patients with mild to moderate intestinal BD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14690","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T15:37:35Z","timestamp":1556120255000},"page":"1929-1939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Remission induction, maintenance, and endoscopic outcome with oral 5\u2010aminosalicylic acid in intestinal Beh\u00e7et's disease"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8179-6017","authenticated-orcid":false,"given":"Hiroto","family":"Kinoshita","sequence":"first","affiliation":[{"name":"Inflammatory Bowel Disease Center Yokohama City University Medical Center  Yokohama Japan"},{"name":"Department of Gastroenterology The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Ikoma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Idzuro Imamura Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Sameshima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Idzuro Imamura Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehisa","family":"Ohi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Idzuro Imamura Hospital  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuki","family":"Tatsuno","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junka","family":"Kouyama","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center Yokohama City University Medical Center  Yokohama 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