{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:44:52Z","timestamp":1754109892154,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Functional gastrointestinal disorders are the most common disorders in gastroenterology and are currently considered as gut\u2013brain interaction disorders with multiple related factors including motility disturbance. However, high\u2010resolution manometry (HRM) had revealed a new disease concept known as minor esophageal motility disorders. This study aimed to investigate the correlation between functional esophageal disorders (FEDs) and minor esophageal motility disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Functional esophageal disorders were diagnosed using upper endoscopy, pH monitoring, and HRM, to exclude achalasia, esophago\u2010gastric junction outflow obstruction, and other major esophageal motility disorders. FEDs with or without minor esophageal motility disorders were compared using the Chicago classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve healthy volunteers also subjected to HRM showed no minor esophageal motility disorders. Of the 40 patients with FEDs, 15 (37.5%) were diagnosed with minor esophageal motility disorders. Characteristics were not different between patients with and without minor esophageal motility disorders (sex: <jats:italic>P<\/jats:italic>\u00a0=\u00a00.609, age: <jats:italic>P<\/jats:italic>\u00a0=\u00a00.054, body mass index: <jats:italic>P<\/jats:italic>\u00a0=\u00a00.137, and presence of psychiatric disorders: <jats:italic>P<\/jats:italic>\u00a0=\u00a00.404). The type and location of symptoms were not related to the comorbidity rate of minor esophageal motility disorders (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.744 and 0.094). No patients with FEDs developed major esophageal motility disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Minor esophageal motility disorders were frequently observed in FEDs, but the causal relationship between esophageal symptoms remains unclear. The disease concepts of FEDs and minor esophageal motility disorders are considered to overlap and are both independent of major esophageal motility disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14691","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T01:34:41Z","timestamp":1556674481000},"page":"1940-1945","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Overlap in disease concept of functional esophageal disorders and minor esophageal motility disorders"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7766-3724","authenticated-orcid":false,"given":"Hiroki","family":"Sato","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Niigata University Medical and Dental Hospital  Niigata 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