{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T19:59:52Z","timestamp":1770667192921,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["Reference no.: 12130211"],"award-info":[{"award-number":["Reference no.: 12130211"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Treatment options for functional dyspepsia (FD) refractory to pharmacological treatments are limited but the effectiveness of electroacupuncture (EA) is uncertain. We assessed the effectiveness of EA combined with on\u2010demand gastrocaine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a single\u2010center, assessor\u2010blind, randomized parallel\u2010group 2\u2010arm trial on <jats:italic>Helicobacter<\/jats:italic> <jats:styled-content style=\"fixed-case\"><jats:italic>pylori<\/jats:italic><\/jats:styled-content> negative FD patients of the postprandial distress syndrome subtype refractory to proton pump inhibitor, prokinetics, or H<jats:sub>2<\/jats:sub> antagonists. Enrolled participants were block randomized in a 1:1 ratio, with concealed random sequence. The treatment and control groups both received on\u2010demand gastrocaine for 12\u00a0weeks, but only those in treatment group were offered 20 sessions of EA over 10\u00a0weeks. The primary endpoint was the between\u2010group difference in proportion of patients achieving adequate relief of symptoms at week 12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 132 participants randomly assigned to EA plus on\u2010demand gastrocaine (<jats:italic>n<\/jats:italic>\u00a0=\u00a066) or on\u2010demand gastrocaine alone (<jats:italic>n<\/jats:italic>\u00a0=\u00a066), 125 (94.7%) completed all follow\u2010up at 12\u00a0weeks. The EA group had a compliance rate 97.7%. They had a significantly higher likelihood in achieving adequate symptom relief at 12\u00a0weeks, with a clinically relevant number needed to treat (NNT) value of 2.36 (95% CI: 1.74, 3.64). Among secondary outcomes, statistically and clinically significant improvements were observed among global symptom (NNT\u00a0=\u00a03.85 [95% CI: 2.63, 7.69]); postprandial fullness and early satiation (NNT\u00a0=\u00a05.00 [95% CI: 2.86, 25.00]); as well as epigastric pain, epigastric burning, and postprandial nausea (NNT\u00a0=\u00a04.17 [95% CI: 2.56, 11.11]). Adverse events were minimal and nonsignificant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For refractory FD, EA provides significant, clinically relevant symptom relief when added to on\u2010demand gastrocaine (ChiCTR\u2010IPC\u201015007109).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14737","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T22:35:13Z","timestamp":1558564513000},"page":"2077-2085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Electroacupuncture plus on\u2010demand gastrocaine for refractory functional dyspepsia: Pragmatic randomized trial"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5947-4492","authenticated-orcid":false,"given":"Vincent CH","family":"Chung","sequence":"first","affiliation":[{"name":"Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong  Shatin Hong Kong"},{"name":"School of Chinese Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2623-5855","authenticated-orcid":false,"given":"Charlene HL","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Shatin Hong Kong"},{"name":"Hong Kong Institute of Integrative Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene XY","family":"Wu","sequence":"additional","affiliation":[{"name":"Xiang\u2010Ya School of Public Health Central South University  Chang\u2010Sha Hu\u2010Nan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica YL","family":"Ching","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Shatin Hong Kong"},{"name":"Hong Kong Institute of Integrative Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William KW","family":"Cheung","sequence":"additional","affiliation":[{"name":"Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin HK","family":"Yip","sequence":"additional","affiliation":[{"name":"Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kam Leung","family":"Chan","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine The Chinese University of Hong Kong  Shatin Hong Kong"},{"name":"Hong Kong Institute of Integrative Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pui Kuan","family":"Cheong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Shatin Hong Kong"},{"name":"Hong Kong Institute of Integrative Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin CY","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Shatin Hong Kong"},{"name":"Hong Kong Institute of Integrative Medicine The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307843"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.099846"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.011"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30003-7"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12355"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.154"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.020"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30303-0"},{"key":"e_1_2_5_10_1","article-title":"Prokinetics for functional dyspepsia","volume":"3","author":"Pittayanon R","year":"2018","journal-title":"Cochrane Database Syst. 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