{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:45:30Z","timestamp":1769165130909,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Vedolizumab (VDZ) has been used in inflammatory bowel disease (IBD) patients who failed anti\u2010tumor necrosis factor (TNF) therapy. This study was to examine long\u2010term outcome of IBD patients switching to VDZ from anti\u2010TNF agents for reasons other than failure of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Inflammatory bowel disease patients at the University of Chicago IBD center who were in clinical remission with anti\u2010TNF therapy and then electively changed to VDZ due to reasons other than loss of response were retrospectively analyzed. The primary outcome was the durability of clinical remission maintained by VDZ as assessed by Kaplan\u2013Meier survival analysis. The proportion of patients in clinical and endoscopic remission at 6\u201312\u00a0months after switching to VDZ therapy was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 41 patients (36 with Crohn's disease and 5 with ulcerative colitis) met the inclusion criteria and were in clinical remission at the time of switch. The majority of patients switched therapy due to adverse effects (56.1%) or infections (14.6%). During a median duration of 30\u00a0months (range 7\u201352) of VDZ therapy, 34 (82.9%) were in VDZ\u2010maintained clinical remission. One (2.4%) and four (9.8%) patients discontinued VDZ due to flare and adverse effects, respectively. Endoscopic remission was present in 25 of 30 patients (83.3%) who had a follow\u2010up colonoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vedolizumab was effective and safe in maintaining remission in IBD patients who switched from anti\u2010TNF agents due to reasons other than failure of therapy. Our results suggest that switching anti\u2010TNF remitters to VDZ treatment is a safe practice in specific patient populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14751","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T14:19:04Z","timestamp":1559830744000},"page":"2090-2095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Outcome of elective switching to vedolizumab in inflammatory bowel disease patients under tumor necrosis factor antagonist\u2010maintained clinical remission"],"prefix":"10.1111","volume":"34","author":[{"given":"Yunwei","family":"Wang","sequence":"first","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Wang","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Pekow","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushila","family":"Dalal","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell D","family":"Cohen","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Ollech","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Israel","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin D","family":"Shogan","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejan","family":"Micic","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Cannon","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Umanskiy","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Hurst","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Hyman","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T","family":"Rubin","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-6129","authenticated-orcid":false,"given":"Atsushi","family":"Sakuraba","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j2505"},{"key":"e_1_2_6_3_1","first-page":"657","article-title":"What to do when biologic agents are not working in inflammatory bowel disease patients","volume":"11","author":"Dalal SR","year":"2015","journal-title":"Gastroenterol. 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