{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:22:50Z","timestamp":1792592570850,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T00:00:00Z","timestamp":1564444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The fund of clinical research","award":["2016ZSLC08"],"award-info":[{"award-number":["2016ZSLC08"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tissue adhesive injection is the first\u2010line treatment for gastric varices rebleeding. Available studies are focused on antibiotic usage in emergency endoscopy, while the use of antibiotics in selective endoscopic tissue adhesive treatment remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a randomized controlled study conducted in a tertiary referral hospital. Consecutive patients were enrolled from February 16, 2016, to November 19, 2016, and blindly randomized into two treatment groups. Patients in the prophylactic group received 2\u00a0g of cefotiam during endoscopic injection of tissue adhesive. All the subjects were observed for rebleeding, fever, and changes in laboratory indicators in hospital and post\u2010discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>One hundred and seven patients who received endoscopic therapy for gastroesophageal varices were included. Fifty\u2010three patients were allocated to the antibiotic prophylactic group and 54 patients to the on\u2010demand group. The two groups had similar baseline characteristics. The incidence of fever in hospital was 2\/53 (3.8%) <jats:italic>vs<\/jats:italic> 9\/54 (16.7%) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.028). Perioperative and postoperative clinical events were significantly lower in the antibiotic prophylactic group (5.7% <jats:italic>vs<\/jats:italic> 24.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018; 7.5% <jats:italic>vs<\/jats:italic> 20.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.050). Inflammation indices were elevated on the first day after endoscopic therapy; however, no significant difference was observed between the two groups. The cumulative rebleeding free rate within 2\u00a0months was lower in the antibiotic prophylactic group (1.9% <jats:italic>vs<\/jats:italic> 9.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.100).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study illustrated that prophylactic use of antibiotics in selective endoscopic injection of tissue adhesive reduced the incidence of the total clinical events in perioperative period and had a trend towards lower rebleeding in 2\u00a0months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14769","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T11:35:00Z","timestamp":1561635300000},"page":"1486-1491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prophylactic use of antibiotics in endoscopic injection of tissue adhesive for the elective treatment of gastric varices: A randomized controlled study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4239-2607","authenticated-orcid":false,"given":"Chengfeng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9798-6296","authenticated-orcid":false,"given":"Lili","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Center Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7413-2685","authenticated-orcid":false,"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Zhongshan Hospital, Fudan University  Shanghai 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