{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:22:42Z","timestamp":1791926562813,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> is one of the main causes of digestive diseases, which is difficult to treat and requires the administration of several antimicrobial agents. Considering the anti\u2010inflammatory and antibacterial effect of atorvastatin, the present study aimed at adding this agent to a four\u2010drug regimen in order to eradicate <jats:italic>H.\u00a0pylori<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 220 patients with <jats:italic>H.\u00a0pylori<\/jats:italic> infection were included in the current randomized controlled clinical trial. In the current study, 110 patients in the control group received a 14\u2010day regimen of amoxicillin, clarithromycin, bismuth, and esomeprazole, and 110 patients in the intervention group received 40\u00a0mg of atorvastatin daily plus the antibiotic regimen for 14\u00a0weeks. The treatment results were evaluated 1\u00a0month later using <jats:italic>H.\u00a0pylori<\/jats:italic> stool antigen test. Data were collected using checklist and analyzed using chi\u2010squared and Fisher's exact tests with <jats:sc>spss<\/jats:sc> version 18.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> eradication rate in the intervention and control groups was 78.18% and 65.45%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.025), and there was a significant difference in terms of non\u2010ulcer dyspepsia between the groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.049), but there was no significant difference in age, gender, and body mass index between the two groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study results showed that adding atorvastatin to the four\u2010drug regimen of omeprazole, clarithromycin, bismuth, and amoxicillin is effective in the eradication of <jats:italic>H.\u00a0pylori<\/jats:italic>. Also, the addition of atorvastatin to <jats:italic>H.\u00a0pylori<\/jats:italic> eradication therapy is more effective in patients with non\u2010ulcer dyspepsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14810","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T04:18:22Z","timestamp":1564460302000},"page":"71-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Atorvastatin in combination with conventional antimicrobial treatment of <i>Helicobacter pylori<\/i> eradication: A randomized controlled clinical trial"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5702-7410","authenticated-orcid":false,"given":"Seyed Saeed","family":"Sarkeshikian","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Disease Research Center Qom University of Medical Sciences  Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5674-3477","authenticated-orcid":false,"given":"Mohammad Reza","family":"Ghadir","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Disease Research Center Qom University of Medical Sciences  Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0636-4847","authenticated-orcid":false,"given":"Faezeh","family":"Alemi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Disease Research Center Qom University of Medical Sciences  Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4148-1037","authenticated-orcid":false,"given":"Seyed Mahdi","family":"Jalali","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Disease Research Center Qom University of Medical Sciences  Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1322-1318","authenticated-orcid":false,"given":"Ahmad","family":"Hormati","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Disease Research Center Qom University of Medical Sciences  Qom Iran"},{"name":"Gastrointestinal and Liver Disease Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3142-6413","authenticated-orcid":false,"given":"Abolfazl","family":"Mohammadbeigi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Qom University of Medical Sciences  Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9638-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_6_4_1","first-page":"Oc09","article-title":"The effect of statins use on the risk and outcome of acute bacterial infections in adult patients","volume":"9","author":"Nassaji M","year":"2015","journal-title":"J. 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