{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:53:40Z","timestamp":1784336020204,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013227","name":"Health Promotion Administration, Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW106\u2010TDU\u2010B\u2010211\u2010113002,MOHW107\u2010TDU\u2010B\u2010211\u2010123002"],"award-info":[{"award-number":["MOHW106\u2010TDU\u2010B\u2010211\u2010113002,MOHW107\u2010TDU\u2010B\u2010211\u2010123002"]}],"id":[{"id":"10.13039\/100013227","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 104\u2010P05, NTUH 105\u2010P05, NTUH 106 \u2010P06"],"award-info":[{"award-number":["NTUH 104\u2010P05, NTUH 105\u2010P05, NTUH 106 \u2010P06"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 106\u2010M3604, NTUH 107\u2010M3994, and NTUH 107\u2010P05"],"award-info":[{"award-number":["NTUH 106\u2010M3604, NTUH 107\u2010M3994, and NTUH 107\u2010P05"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 107\u2010P05"],"award-info":[{"award-number":["NTUH 107\u2010P05"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The reported prevalence of <jats:italic>Helicobacter pylori<\/jats:italic> infection in Taiwan was 54.4% in 1992. An updated prevalence of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> infection in asymptomatic adults is lacking in Taiwan. We aimed to assess the updated age\u2010standardized prevalence of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> infection in asymptomatic subjects and in patients with dyspepsia and to assess the accuracy of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> stool antigen (HpSA) test for screening of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> in Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Asymptomatic adult subjects (<jats:italic>N<\/jats:italic>\u00a0=\u00a0189) were screened for <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> infection using HpSA, serology, and <jats:sup>13<\/jats:sup>C\u2010urea breath test (<jats:sup>13<\/jats:sup>C\u2010UBT) in 2016\u20132017. Adult patients with dyspepsia (<jats:italic>N<\/jats:italic>\u00a0=\u00a0145) were screened for <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> using <jats:sup>13<\/jats:sup>C\u2010UBT, HpSA, serology, rapid urease test, and histology during 2016\u20132018. Two types of HpSA, including the Diagnostec HpSA ELISA Kit (HpSA ELISA) and Rapid Test Kit (HpSA Rapid), were used in this study. Sensitivity, specificity, and accuracy of the HpSA tests were calculated using the <jats:sup>13<\/jats:sup>C\u2010UBT as golden standard test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The unadjusted prevalence of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> was 21.2% in asymptomatic adults and 37.9% in patients with dyspepsia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The age\u2010standardized prevalence of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> was 28.9% in asymptomatic adults in Taiwan. Of the 334 patients included for analysis, the area under the curve of HpSA ELISA test was 0.978, and the optimal cutoff value of optical density was 0.03. The sensitivity, specificity, and accuracy of the HpSA ELISA were 0.929, 0.983, and 0.967, respectively. The sensitivity, specificity, and accuracy of the HpSA Rapid were 0.929, 0.958, and 0.949, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> infection has decreased in Taiwan. HpSA test is an accurate tool for screening of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> in Chinese population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14828","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T21:32:57Z","timestamp":1565731977000},"page":"233-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Application of <i>Helicobacter pylori<\/i> stool antigen test to survey the updated prevalence of <i>Helicobacter pylori<\/i> infection in Taiwan"],"prefix":"10.1111","volume":"35","author":[{"given":"Mei\u2010Jyh","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Institute of Occupational Medicine and Industry Hygiene National Taiwan University College of Public Health  Taipei Taiwan"},{"name":"Integrated Diagnostics and Therapeutics National Taiwan University Hospital, National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Jen","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital, Yun\u2010Lin Branch, National Taiwan University College of Medicine  Yunlin Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Shiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh\u2010Chang","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Nien","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Chun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital, Yun\u2010Lin Branch, National Taiwan University College of Medicine  Yunlin Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Chi","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital, Yun\u2010Lin Branch, National Taiwan University College of Medicine  Yunlin Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Chin","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital, Yun\u2010Lin Branch, National Taiwan University College of Medicine  Yunlin Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Hao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital, Hsin\u2010Chu Branch  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Horn","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital, Hsin\u2010Chu Branch  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Lin","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital, Hsin\u2010Chu Branch  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital, Hsin\u2010Chu Branch  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Jong","family":"Bair","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Mackay Memorial Hospital, Taitung Branch  Taitung Taiwan"},{"name":"Mackay Medical College  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7945-5408","authenticated-orcid":false,"given":"Jyh\u2010Ming","family":"Liou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Taiwan Gastrointestinal Disease and Helicobacter Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/314785"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001110"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g3174"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.96"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529309098311"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000225658.30803.79"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i30.3841"},{"key":"e_1_2_6_10_1","first-page":"85","article-title":"Long\u2010term follow\u2010up of Helicobacter pylori serology after successful eradication","volume":"91","author":"Cutler AF","year":"1996","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_6_11_1","first-page":"1699","article-title":"Prospective blinded trial of a fecal antigen test for the detection of Helicobacter pylori infection","volume":"95","author":"Vakil N","year":"2000","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.212.159"},{"key":"e_1_2_6_14_1","unstructured":"National Statistics R.O.C. (Taiwan)https:\/\/www.stat.gov.tw\/ct.asp?xItem=15408&CtNode=3623&mp=4. Accessed December 2 2018."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0780-4"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1004057"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.198309"},{"key":"e_1_2_6_18_1","unstructured":"National Health Insurance Research Institute.National Health Insurance Research Database. Available fromhttps:\/\/www.nhi.gov.tw\/Default.aspx. Accessed December 2 2018."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-015855"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00874.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.12.029"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14561"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2006.11.002"},{"key":"e_1_2_6_24_1","first-page":"CD012080","article-title":"Non\u2010invasive diagnostic tests for Helicobacter pylori infection","author":"Best LM","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00668.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.07065.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2005.03.012"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-1033-x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00276.x"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14828","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.14828","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T02:49:12Z","timestamp":1694141352000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.14828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/jgh.14828"],"URL":"https:\/\/doi.org\/10.1111\/jgh.14828","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]},"assertion":[{"value":"2018-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}