{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:13:34Z","timestamp":1770534814964,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["lzujbky\u20102018\u2010kb13"],"award-info":[{"award-number":["lzujbky\u20102018\u2010kb13"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770537"],"award-info":[{"award-number":["31770537"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>It has been well documented that<jats:italic>Helicobacter pylori<\/jats:italic>(<jats:italic>H.\u00a0pylori<\/jats:italic>) infection is a risk factor for aggravating gastric mucosal atrophy. However, the exact molecular mechanism mediating this process is not fully elucidated. The purpose of this study was to identify biomarkers, which may predict the risk for progression of chronic atrophic gastritis (CAG) with<jats:italic>H.\u00a0pylori<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>GSE27411 was downloaded from the Gene Expression Omnibus. The differentially expressed genes (DEGs) between<jats:italic>H.\u00a0pylori<\/jats:italic>\u2010infected samples without CAG and<jats:italic>H.\u00a0pylori<\/jats:italic>\u2010infected CAG samples were analyzed. Gene Ontology and pathway enrichment analyses were performed, followed by protein\u2013protein interaction network construction. We used immunohistochemistry analysis to identify DEGs in 20 chronic gastritis, 20 CAG, and 22 gastric cancer (GC) specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 303 upregulated and 26 downregulated DEGs were identified. The pathways enriched by upregulated DEGs were mainly related to fat digestion and absorption, peroxisome proliferator\u2010activated receptor signaling pathway, and chemical carcinogenesis. Cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) had the highest degrees in protein\u2013protein interaction network. Moreover, the positive rates of CYP3A4 protein expression in chronic gastritis, CAG, and GC were 10% (2\/20), 55% (11\/20), and 77.3% (17\/22), respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The Kaplan\u2013Meier analysis revealed that elevated expression of CYP3A4 was significantly associated with worse overall survival and first progression, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to the findings of this study, the expression of CYP3A4 might be related to the potential carcinogenic transformation of CAG to GC. Therefore, CYP3A4 may be biomarkers to predict progression of CAG and poor prognosis of gastric cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14844","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T13:59:29Z","timestamp":1566568769000},"page":"425-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prediction of progression of chronic atrophic gastritis with<i>Helicobacter pylori<\/i>and poor prognosis of gastric cancer by CYP3A4"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6442-6516","authenticated-orcid":false,"given":"Fan","family":"Zhang","sequence":"first","affiliation":[{"name":"Lanzhou University Second Hospital Lanzhou Gansu China"},{"name":"Key Laboratory of Digestive System Tumors of Gansu Province Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furong","family":"Wang","sequence":"additional","affiliation":[{"name":"Lanzhou University Second Hospital Lanzhou Gansu China"},{"name":"Key Laboratory of Digestive System Tumors of Gansu Province Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0875-7473","authenticated-orcid":false,"given":"Cong","family":"Chen","sequence":"additional","affiliation":[{"name":"Lanzhou University Second Hospital Lanzhou Gansu China"},{"name":"Key Laboratory of Digestive System Tumors of Gansu Province Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Lanzhou University Second Hospital Lanzhou Gansu China"},{"name":"Key Laboratory of Digestive System Tumors of Gansu Province Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jike","family":"Hu","sequence":"additional","affiliation":[{"name":"Lanzhou University Second Hospital Lanzhou Gansu China"},{"name":"Key Laboratory of Digestive System Tumors of Gansu Province Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiliang","family":"Su","sequence":"additional","affiliation":[{"name":"Lanzhou University Second Hospital Lanzhou Gansu China"},{"name":"Key Laboratory of Digestive System Tumors of Gansu Province Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Li","sequence":"additional","affiliation":[{"name":"Lanzhou University Second Hospital Lanzhou Gansu China"},{"name":"Key Laboratory of Digestive System Tumors of Gansu Province Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baohong","family":"Gu","sequence":"additional","affiliation":[{"name":"Lanzhou University Second Hospital Lanzhou Gansu China"},{"name":"Key Laboratory of Digestive System Tumors of Gansu Province Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaojun","family":"Tang","sequence":"additional","affiliation":[{"name":"Innovation Center for Biomedical Informatics Georgetown University Medical Center Washington District of Columbia USA"},{"name":"Department of Oncology Georgetown University Medical Center Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Lanzhou University Second Hospital Lanzhou Gansu China"},{"name":"Key Laboratory of Digestive System Tumors of Gansu Province Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumin","family":"Li","sequence":"additional","affiliation":[{"name":"Lanzhou University Second Hospital Lanzhou Gansu China"},{"name":"Key Laboratory of Digestive System Tumors of Gansu Province Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl16488"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11684"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311685"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9482-0"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28470"},{"key":"e_1_2_5_7_1","first-page":"41","article-title":"Transcriptome signatures in Helicobacter pylori\u2010infected mucosa identifies acidic mammalian chitinase loss as a corpus atrophy marker","volume":"6","author":"Nookaew I","year":"2013","journal-title":"BMC Med. 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