{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T02:03:42Z","timestamp":1768269822171,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2018CXGC1209"],"award-info":[{"award-number":["2018CXGC1209"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2017YFC0110003"],"award-info":[{"award-number":["2017YFC0110003"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2017YFC0109700"],"award-info":[{"award-number":["2017YFC0109700"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670489"],"award-info":[{"award-number":["81670489"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The effect of real\u2010time analysis of needle\u2010based confocal laser endomicroscopy (nCLE) for gastric subepithelial lesions (SELs) on the diagnostic value is unclear. The study aimed to investigate the diagnostic efficacy of real\u2010time nCLE for gastric SELs and to assess the technical aspects and safety of real\u2010time nCLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with gastric SELs \u2265\u00a01\u00a0cm were prospectively investigated by endoscopic ultrasound (EUS), followed by nCLE. During EUS\u2010nCLE, real\u2010time nCLE diagnosis was made by an expert endoscopist. The procedure\u2010relative adverse events were assessed and recorded. One\u2010month washout period later, nCLE videos were reviewed off\u2010line by the same endoscopist. The nCLE diagnoses were compared with corresponding pathological results. Additionally, image quality and interobserver agreements for the criteria were evaluated by three experienced endomicroscopists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Except for one failing to be punctured, 60 patients completed EUS\u2010nCLE procedures successfully. Real\u2010time nCLE had high diagnostic accuracies of \u2265\u00a088.3% for gastric SELs. There were no significant differences between real\u2010time and off\u2010line nCLE diagnoses for gastric SELs (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). The overall accuracy of real\u2010time nCLE for diagnosis of gastric SELs was 86.7%. There were no procedure\u2010relative adverse events occurred. In addition, the mean image quality score was 3.6 (1\u00a0=\u00a0poor and 5\u00a0=\u00a0excellent). The interobserver agreement was \u201calmost perfect\u201d for ectopic pancreas and \u201csubstantial\u201d for gastrointestinal stromal tumor, leiomyoma, and carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Endoscopic ultrasound\u2010nCLE could provide in vivo real\u2010time diagnostic imaging with a high diagnostic accuracy. Meanwhile, real\u2010time nCLE was feasible and had a satisfactory safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14863","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T20:35:12Z","timestamp":1568406912000},"page":"446-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["In vivo real\u2010time diagnosis of endoscopic ultrasound\u2010guided needle\u2010based confocal laser endomicroscopy in gastric subepithelial lesions"],"prefix":"10.1111","volume":"35","author":[{"given":"Ming\u2010Ming","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9556-8771","authenticated-orcid":false,"given":"Xiu\u2010Li","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong 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Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9325-4808","authenticated-orcid":false,"given":"Yan\u2010Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong 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