{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T20:35:20Z","timestamp":1774038920348,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2018CXGC1209"],"award-info":[{"award-number":["2018CXGC1209"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670489"],"award-info":[{"award-number":["81670489"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Cresyl violet (CV) is a topical dye that allows simultaneous chromoendoscopy and <jats:italic>in vivo<\/jats:italic> confocal laser endomicroscopy in identification of neoplastic changes of the lower gastrointestinal tract without intravenous injection of fluorescein, but as yet no investigation has reported its application in the diagnosis of gastric intestinal metaplasia (GIM). This study aims to assess the feasibility as well as diagnosis accuracy of topical CV for <jats:italic>in vivo<\/jats:italic> diagnosis of GIM by using probe\u2010based confocal laser endomicroscopy (pCLE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective, open\u2010label, feasibility study, 129 confocal videos from 22 patients with known GIM were analyzed and compared with corresponding histological images to establish the CV staining characteristics. In addition, 47 patients with known or suspected GIM were prospectively enrolled to evaluate the accuracy of this topical CV endomicroscopic imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Probe\u2010based confocal laser endomicroscopy with topical CV enabled clear visualization of the goblet cells, absorptive cells, and intestinal villi of GIM. The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of pCLE diagnosis of GIM on a per\u2010location analysis was 93.01%, 91.95%, 93.51%, 86.96%, and 96.11%, respectively. The intraclass correlation coefficient for inter\u2010observer agreement and mean kappa value for intra\u2010observer agreement for the diagnosis of GIM was 0.82 and 0.87, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Topical CV enables real\u2010time chromoendoscopy in conjunction with pCLE examination of the stomach and warrants accurate diagnosis of GIM. It may be an acceptable and potentially alternative dye for confocal imaging in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14864","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T20:35:40Z","timestamp":1568406940000},"page":"453-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cresyl violet as a new contrast agent in probe\u2010based confocal laser endomicroscopy for <i>in vivo<\/i> diagnosis of gastric intestinal metaplasia"],"prefix":"10.1111","volume":"35","author":[{"given":"Yi\u2010Ning","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Qilu Hospital Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Qilu Hospital Shandong University  Jinan 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