{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:14:26Z","timestamp":1790633666330,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["107\u2010T11"],"award-info":[{"award-number":["107\u2010T11"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013227","name":"Health Promotion Administration, Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["10703003671"],"award-info":[{"award-number":["10703003671"]}],"id":[{"id":"10.13039\/100013227","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The aim of this study is to identify gastric cancer burden in Indigenous Taiwanese peoples and conduct a project to evaluate how to reduce the disparities most effectively in Indigenous communities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>First, we quantified the health disparities in gastric cancer in Indigenous peoples using data from the cancer registries during the period of 2006\u20132014. Second, we identified parameters that might be associated with <jats:italic>Helicobacter pylori<\/jats:italic> infection or help identify a good eradication strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gastric cancer incidence (24.4 <jats:italic>vs<\/jats:italic> 12.3 per 100\u00a0000 person\u2010years) and mortality rates (15.8 <jats:italic>vs<\/jats:italic> 6.8 per 100\u00a0000 person\u2010years) were higher in Indigenous than in non\u2010Indigenous, with 2.19\u2010fold (95% confidence interval [CI]: 2.06\u20132.33) and 2.47\u2010fold (2.28\u20132.67) increased risk, respectively. In Indigenous communities, <jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic><\/jats:styled-content> infection was more prevalent in Indigenous than in non\u2010Indigenous (59.4% <jats:italic>vs<\/jats:italic> 31.5%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Regression analyses consistently showed that either the mountain or plain Indigenous had 1.89\u2010fold (95% CI: 1.34\u20132.66) and 1.73\u2010fold (95% CI: 1.24\u20132.41) increased risk for <jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic><\/jats:styled-content> infection, respectively, as compared with non\u2010Indigenous, adjusting for other baseline characteristics. The high infection rates were similarly seen in young, middle\u2010aged, and older adults. Program eradication rates using clarithromycin\u2010based triple therapy were suboptimal (73.7%, 95% CI: 70.0\u201377.4%); the habits of smoking (1.70\u2010fold, 95% CI: 1.01\u20132.39) and betel nut chewing (1.54\u2010fold, 95% CI: 0.93\u20132.16) were associated with the higher risk of treatment failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Gastric cancer burden is higher in Indigenous Taiwanese peoples than in their non\u2010Indigenous counterparts. Eliminating the prevalent risk factor of <jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic>.\u00a0<jats:italic>pylori<\/jats:italic><\/jats:styled-content> infection is a top priority to reduce this health disparity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14898","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T02:05:57Z","timestamp":1572660357000},"page":"609-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Planning mass eradication of <scp><i>Helicobacter pylori<\/i><\/scp> infection for indigenous Taiwanese peoples to reduce gastric cancer"],"prefix":"10.1111","volume":"35","author":[{"given":"Ming\u2010Jong","family":"Bair","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Taitung Mackey Memorial Hospital  Taitung Taiwan"},{"name":"Mackay Medical College  New Taipei City 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