{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:52:40Z","timestamp":1754488360196,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Treatment modalities of variceal bleeding or rebleeding for extrahepatic portal vein obstruction (EHPVO) are limited, and their long\u2010term results and prognostic factors are unclear. This study aimed at assessing the long\u2010term results of EHPVO treated with current recommendations and investigating the influencing factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2009 and 2016, 302 consecutive patients with EHPVO were included. Watch\u2010and\u2010wait policy was applied for those with no (<jats:italic>n<\/jats:italic>\u00a0=\u00a059) or small varices (<jats:italic>n<\/jats:italic>\u00a0=\u00a055), nonselective beta\u2010adrenergic blocker and nonselective beta\u2010adrenergic blocker plus endotherapy were for primary (<jats:italic>n<\/jats:italic>\u00a0=\u00a0115) and secondary prophylaxis (<jats:italic>n<\/jats:italic>\u00a0=\u00a087), transjugular intrahepatic portosystemic shunt (TIPS) or combination therapy was for those with recurrent bleeding (<jats:italic>n<\/jats:italic>\u00a0=\u00a092).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow up was 58.8\u00a0months. The 1\u2010, 3\u2010, and 5\u2010year cumulative rates were 3.6%, 19.2%, 32.3% for small varices development and 4.5%, 30.9%, 53.4% for large varices development. The 1\u2010, 3\u2010, and 5\u2010year cumulative rates were 11.1%, 20.9%, and 34.9% for first variceal bleeding and 16.0%, 26.9%, and 33.6% for variceal rebleeding. For those with recurrent variceal bleeding, only TIPS (<jats:italic>n<\/jats:italic>\u00a0=\u00a037, technical success rate: 90.2%) was associated with a reduced risk of variceal rebleeding (1\u2010, 3\u2010, and 5\u2010year: 5.6%, 11.7%, and 21.9%). The 1\u2010, 3\u2010, and 5\u2010year survival rates were 96.9%, 95.8%, and 91.9%. Prothrombotic factors and anticoagulation did not influence the risk of variceal bleeding, rebleeding, and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>By applying the same variceal management as recommended for patients with liver cirrhosis, patients with non\u2010cirrhotic EHPVO showed a similar development of varices and variceal bleeding. This is also true for the beneficial effect of TIPS to prevent rebleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14902","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T02:03:02Z","timestamp":1572660182000},"page":"1049-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Long\u2010term results of variceal bleeding management in 302 patients with chronic extrahepatic portal vein obstruction"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8627-0049","authenticated-orcid":false,"given":"Hui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Liver Diseases and Digestive Interventional Radiology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases Fourth Military Medical University  Xi'an 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Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihao","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Liver Diseases and Digestive Interventional Radiology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Liver Diseases and Digestive Interventional Radiology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases Fourth Military Medical University  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Liver 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