{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:44:01Z","timestamp":1789670641691,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005866","name":"Far Eastern Memorial Hospital","doi-asserted-by":"publisher","award":["FEMH\u20102016D037"],"award-info":[{"award-number":["FEMH\u20102016D037"]}],"id":[{"id":"10.13039\/501100005866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["107\u2010M3973"],"award-info":[{"award-number":["107\u2010M3973"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The clinicopathologic features of hepatocellular adenoma in Asian populations have been poorly defined. The study aimed to characterize this rare entity in a single institution in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 45 hepatocellular adenomas from 1995 to 2018 were included and sent for pathologic review and molecular subtyping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The numbers of patients with hepatocellular adenoma has doubled in the recent decade. Surprisingly, men outnumbered women in our cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a026, 58% <jats:italic>vs N<\/jats:italic>\u00a0=\u00a019, 42%). A collection of clinical information revealed that overweight\/obesity accounts for most of the associated conditions of hepatocellular adenoma. Only three women took oral contraceptives. There were 34 inflammatory (75%), three LFABP\u2010negative (7%), four \u03b2\u2010catenin activated (9%), and four unclassified (9%) hepatocellular adenomas. Ten inflammatory hepatocellular adenomas demonstrated strong and homogeneous glutamine synthetase staining and were thus also \u03b2\u2010catenin activated. Notably, overweight and obesity were significantly associated with inflammatory hepatocellular adenoma than other subtypes (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.029 and .056, respectively) and were strongly correlated with steatosis in background liver (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.028 and.007, respectively). Malignant transformation (four borderline tumors and two hepatocellular carcinomas) was identified in six adenomas (two women and four men). All six hepatocellular adenomas with malignancy were \u03b2\u2010catenin activated; \u03b2\u2010catenin activation could serve as a biomarker for malignant progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The clinicopathologic features of hepatocellular adenoma in Taiwan are distinct from those reported in Western countries. Rare oral contraceptive usage and an emerging epidemic of overweight\/obesity in Taiwan provides new insights into the pathogenesis of hepatocellular adenoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14903","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T23:07:40Z","timestamp":1573168060000},"page":"680-688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Hepatocellular adenoma in Taiwan: Distinct ensemble of male predominance, overweight\/obesity, and inflammatory subtype"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0484-4708","authenticated-orcid":false,"given":"Wen\u2010Chih","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Anatomic Pathology Far Eastern Memorial Hospital  New Taipei Taiwan"},{"name":"College of Nursing National Taipei University of Nursing and Health Sciences  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jau\u2010Yu","family":"Liau","sequence":"additional","affiliation":[{"name":"Department of Pathology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Pathology, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung\u2010Ming","family":"Jeng","sequence":"additional","affiliation":[{"name":"Department of Pathology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Pathology, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kao\u2010Lang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Nan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Fu Jen Catholic University Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang\u2010Lin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology National Taiwan University Hospital, Hsin\u2010Chu Branch  Hsin\u2010Chu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Huei","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Pathology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Pathology, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"198","volume-title":"WHO Classification of Tumours of the Digestive System, World Health Organization Classification of Tumours","author":"Bioulac\u2010Sage P","year":"2010"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.11.042"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.07.009"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21743"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0183-RA"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02786.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.222109"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04772.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.07.061"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0275-6"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06502.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/648131"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2015.09.003"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)92594-4"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197602262940904"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1979.03300070040020"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197910)44:4<1481::AID-CNCR2820440443>3.0.CO;2-1"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(91)90007-3"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2007.00434.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-7435(03)00119-1"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2005.00175.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.1.31"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091987"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21684"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20973"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2862173"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02679990"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.09.030"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1086\/345871"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.02.055"},{"key":"e_1_2_5_34_1","first-page":"164","article-title":"Evidence\u2010based assessment on providing preventive health service for adults aged younger than 40 in Taiwan","volume":"27","author":"Huang CF","year":"2017","journal-title":"Taiwan J Fam Med."}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.14903","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14903","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.14903","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T04:21:54Z","timestamp":1694060514000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.14903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,7]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/jgh.14903"],"URL":"https:\/\/doi.org\/10.1111\/jgh.14903","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,7]]},"assertion":[{"value":"2019-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}