{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:23:36Z","timestamp":1768263816734,"version":"3.49.0"},"reference-count":70,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The efficacy of herbal medicines (HMs) for functional gastrointestinal disorders (FGIDs) including irritable bowel syndrome (IBS), functional dyspepsia (FD) and functional constipation (FC) is controversial. A systematic review with meta\u2010analysis was conducted to determine their effectiveness for FGIDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the following electronic databases till July 2019 with English language restriction: The Cochrane Library, EMBASE and PUBMED. Randomized double\u2010blind controlled trials of HMs compared with placebo or conventional pharmacological drugs for adult FGIDs patients were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 49 trials involving 7396 participants with FGIDs were included. The risk of bias was low in 9, unclear in 36, and high in 4 trials. More than 33 different herbal formulae were tested. HMs demonstrated statistically significant benefits for symptom improvement compared with placebo in 46 trials (RR\u00a0=\u00a01.67, 95% CI 1.48\u20131.88). When compared with conventional pharmacological therapy in 5 trials, HMs were found to be non\u2010inferior (RR\u00a0=\u00a01.10, 95% CI 1.03\u20131.18). The number of trials with regards to FD, IBS and FC were 19, 23 and 7 respectively. Subgroup analysis found that HMs were better than placebo in alleviating symptoms for FD (RR\u00a0=\u00a01.50, 95% CI 1.32\u20131.69), IBS (RR\u00a0=\u00a01.62, 95% CI 1.32\u20131.97) and FC (RR\u00a0=\u00a03.83, 95% CI 2.26\u20136.50). HMs tended to have more patients with adverse events than placebo, but similar to conventional pharmacological drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings provide a positive signal for HMs as a potentially well\u2010tolerated and effective treatment for FGIDs, deserving further examination in high\u2010quality trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14905","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T01:59:56Z","timestamp":1572573596000},"page":"544-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta\u2010analysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6456-7482","authenticated-orcid":false,"given":"Niandi","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kok Ann","family":"Gwee","sequence":"additional","affiliation":[{"name":"Department of Medicine National University of Singapore and Gleneagles Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Tack","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases, Metabolism and Ageing University of Leuven  Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-1103","authenticated-orcid":false,"given":"Mengyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minhu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinglian","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14165"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12355"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15191"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.078089"},{"key":"e_1_2_5_7_1","first-page":"244","article-title":"Consumption of medicinal herbs in patients attending a gastroenterology outpatient clinic","volume":"27","author":"Devesa JF","year":"2004","journal-title":"Gastroenterol. 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