{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:14:12Z","timestamp":1791825252292,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81330014"],"award-info":[{"award-number":["81330014"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81570486"],"award-info":[{"award-number":["81570486"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81800463"],"award-info":[{"award-number":["81800463"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Small intestinal bacterial overgrowth (SIBO) has been proposed as an etiologic factor in irritable bowel syndrome, particularly the diarrhea\u2010predominant subtype (IBS\u2010D). We aimed to identify potential intestinal microbial pattern in IBS\u2010D patients with SIBO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Diarrhea\u2010predominant irritable bowel syndrome patients fulfilling Rome III criteria were recruited and randomly divided into an exploratory cohort (57 cases) and a validation cohort (20 cases). SIBO was identified according to standard glucose hydrogen breath test. For 16S rRNA gene sequencing, samples of duodenal mucosa, duodenal fluid, rectal mucosa, and fresh feces were collected and performed. The \u03b1 and \u03b2 diversity, as well as differences in microbial composition and function, in SIBO\n                      <jats:sup>+<\/jats:sup>\n                      and SIBO\n                      <jats:sup>\u2212<\/jats:sup>\n                      IBS\u2010D subjects were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The microbial diversity and composition obviously differed between SIBO\n                      <jats:sup>+<\/jats:sup>\n                      and SIBO\n                      <jats:sup>\u2212<\/jats:sup>\n                      IBS\u2010D in duodenal and rectal mucosa but not in duodenal fluid and fresh feces. For rectal mucosal microbiota, it displayed markedly reduced aerobe and Gram\u2010negative bacteria and increased facultative anaerobe and Gram\u2010positive bacteria, moreover, altered functions of microbial metabolism in SIBO\n                      <jats:sup>+<\/jats:sup>\n                      IBS\u2010D. Significantly higher rectal mucosa\u2010related microbial dysbiosis index was observed in SIBO\n                      <jats:sup>+<\/jats:sup>\n                      IBS\u2010D, and a cut\u2010off value at \u22120.37 had a sensitivity of 56.55% and specificity of 90.91% to identify the SIBO in IBS\u2010D subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Mucosal microbiota, rather than luminal bacteria, has a more apparent dysbiosis in SIBO\n                      <jats:sup>+<\/jats:sup>\n                      IBS\u2010D patients relative to those without SIBO. Rectal mucosa\u2010associated microbiota may act as a potential predictor of SIBO in IBS\u2010D patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.14910","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:59:14Z","timestamp":1572569954000},"page":"795-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Duodenal and rectal mucosal microbiota related to small intestinal bacterial overgrowth in diarrhea\u2010predominant irritable bowel syndrome"],"prefix":"10.1111","volume":"35","author":[{"given":"Min","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4921-8986","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaichao","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangping","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qian","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanhua","family":"Xiong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9697-8510","authenticated-orcid":false,"given":"Tao","family":"Bai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0255-4547","authenticated-orcid":false,"given":"Jun","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3694-2126","authenticated-orcid":false,"given":"Xiaohua","family":"Hou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2017.07.009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2017.1383819"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2018.2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1476-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-10-23"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06654.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3872-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2016.1140571"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13437"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.055"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12516"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00154.2011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm15116"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.075127"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.03951.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1412.12047"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061516"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.f.303"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2604"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msp077"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5086-4"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1029"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.02.005"},{"key":"e_1_2_6_27_1","first-page":"133462","article-title":"BugBase predicts organism level microbiome phenotypes","author":"Ward T","year":"2017","journal-title":"BioRxiv"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2676"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu494"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.06.031"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000348"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02189.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000122"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13399"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13055"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1758-2229.2012.00327.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i24.2978"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01600"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14059"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep34055"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000634"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03533.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04625.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.37.319"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441768"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070747"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12750"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95376"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.4161\/21688370.2014.982426"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-9-r79"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.14910","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14910","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.14910","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T16:47:58Z","timestamp":1694018878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.14910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,5]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/jgh.14910"],"URL":"https:\/\/doi.org\/10.1111\/jgh.14910","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,5]]},"assertion":[{"value":"2019-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}