{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:23:43Z","timestamp":1773984223328,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T00:00:00Z","timestamp":1576368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81172145"],"award-info":[{"award-number":["81172145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81420108020"],"award-info":[{"award-number":["81420108020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Comprehensive investigations on the prothrombotic factors of splanchnic vein thrombosis (SVT), including Budd\u2013Chiari syndrome (BCS) and non\u2010cirrhotic nonmalignant portal vein thrombosis (PVT), in Eastern patients are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between March 2012 and July 2017, 812 consecutive patients, including 418 BCS and 394 non\u2010cirrhotic nonmalignant PVT patients, were admitted to Xijing Hospital (a Chinese tertiary academic hospital) and screened for prothrombotic factors. Odds ratios (ORs), 95% confidence intervals (CIs), and <jats:italic>P<\/jats:italic>\u2010trends were calculated by using conditional logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of myeloproliferative neoplasms (MPNs) was only 6.3% among BCS patients but 28.3% among PVT patients. Notably, the presence of MPNs was associated with a higher risk of hepatic vein\u2010type BCS (OR 9.9, 95% CI 3.6\u201326.7, <jats:italic>P<\/jats:italic>\u2010trend &lt;\u00a00.001) and extensive thrombosis in PVT (OR 4.1, 95% CI 1.9\u20138.9, <jats:italic>P<\/jats:italic>\u2010trend &lt;\u00a00.001). Calreticulin mutations existed in 2.7% of SVT patients. Furthermore, the prevalence of antiphospholipid antibody syndrome and protein C, protein S, or antithrombin deficiency in BCS patients was 7.3% and 22.5%, respectively, similar to that in patients with PVT (7.4% and 25.7%). In addition, factor V Leiden mutation, prothrombin G20210A mutation, and paroxysmal nocturnal hemoglobinuria were identified in &lt;\u00a01% of both BCS and PVT patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a significant positive association between MPNs and hepatic vein\u2010type BCS or non\u2010cirrhotic nonmalignant PVT with extensive thrombosis. Additionally, calreticulin mutations should be tested in JAK2<jats:sup><jats:italic>V617F<\/jats:italic><\/jats:sup>\u2010negative SVT patients in China. However, screening for factor V Leiden mutation, prothrombin G20210A mutation, and paroxysmal nocturnal hemoglobinuria may be unnecessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14925","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:13:30Z","timestamp":1573517610000},"page":"1215-1222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prevalence of prothrombotic factors in patients with Budd\u2013Chiari syndrome or non\u2010cirrhotic nonmalignant portal vein thrombosis: A hospital\u2010based observational study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4366-3475","authenticated-orcid":false,"given":"Jiahao","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Liver Disease and Digestive Interventional Radiology, National Clinical Research Center for Digestive Disease and Xijing Hospital of Digestive Diseases 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