{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:43:01Z","timestamp":1785307381432,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Primary biliary cholangitis (PBC) is a chronic, slowly progressive, autoimmune liver disease. Some PBC patients display disease progression regardless of medical treatment. Therefore, it is important to accurately diagnose the clinical stage of PBC. This study investigated clinical merits of vibration\u2010controlled transient elastography using FibroScan for assessing disease stage in PBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 74 treatment\u2010na\u00efve PBC patients (84% female, median age: 64\u00a0years), 69 of whom having undergone histological assessment and five clinically diagnosed as at the cirrhosis stage, were enrolled for clinical comparisons of liver stiffness measurement (LSM) with other established indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of patients with Nakanuma stages 1, 2, 3, and 4 was 18, 33, 17, and 6, respectively. The median LSM values for Nakanuma stages 1, 2, 3, and 4 were 5.05, 5.90, 8.90, and 23.70\u00a0kPa, respectively, and correlated significantly with disease progression based on Nakanuma's classification (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.501, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). LSM was also significantly related to other non\u2010invasive serological markers (Mac\u20102 binding protein glycosylation isomer: <jats:italic>r<\/jats:italic>\u00a0=\u00a00.606, FIB\u20104 index: <jats:italic>r<\/jats:italic>\u00a0=\u00a00.493, and aspartate aminotransferase\u2010to\u2010platelet ratio index: <jats:italic>r<\/jats:italic>\u00a0=\u00a00.577; all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The areas under the receiver operating characteristic curve for diagnosing Nakanuma stage \u2265\u00a02, stage \u2265\u00a03, and stage 4 were 0.744, 0.763, and 0.907, respectively. A combination of LSM \u2265\u00a07.0\u00a0kPa and Mac\u20102 binding protein glycosylation isomer \u2265\u00a01.00 cut\u2010off index could predict late\u2010stage PBC (i.e. moderate to advanced disease progression) with a sensitivity of 0.58, specificity of 0.82, and accuracy of 0.74.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liver stiffness measurement using FibroScan provided simple, accurate, and non\u2010invasive assessment of disease stage in PBC patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14929","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T10:26:06Z","timestamp":1573727166000},"page":"1208-1214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clinical utility of FibroScan as a non\u2010invasive diagnostic test for primary biliary cholangitis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6364-9654","authenticated-orcid":false,"given":"Satoru","family":"Joshita","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0162-4208","authenticated-orcid":false,"given":"Yuki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto 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