{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:01:21Z","timestamp":1754110881943,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Grazoprevir\/elbasvir (GZR\/EBR) was approved for the treatment of chronic hepatitis C virus (HCV) genotype 1 and 4 infected patients with or without compensated liver cirrhosis. The aim of this study was to assess GZR\/EBR regimen in the real\u2010world experience, particularly in previously \u201cdifficult\u2010to\u2010treat\u201d patients with chronic kidney diseases, human immunodeficiency virus\u2010coinfected, cirrhotics, and treatment\u2010experienced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The analysis included patients treated with GZR\/EBR selected from 10 152 individuals from the EpiTer\u20102 database, large national real\u2010world study evaluating antiviral treatment in 22 Polish hepatology centers between 2015 and 2018. Data were completed retrospectively and submitted online.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1615 patients who started GZR\/EBR therapy in 2017 and 2018 with a female predominance (54%) and median age of 54 years were analyzed. The majority were infected with GT1b (89%) and treatment na\u00efve (81%). Liver cirrhosis was diagnosed in 19%, and 70% of patients had comorbidities, of which chronic renal disease was present in 7% and HIV\u2010coinfection in 4%. Overall, a sustained virologic response (SVR) was achieved by 95% according to intent\u2010to\u2010treat (ITT) and 98% after exclusion of lost to follow up (modified ITT). No differences were found in cure rate between all included patients and subpopulations previously considered as difficult\u2010to\u2010treat. Majority of patients completed the treatment course as scheduled, adverse events were mostly mild and did not lead to therapy discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GZR\/EBR treatment carried\u2010out in patients infected with HCV genotype 1 and 4 demonstrated good tolerability and an excellent SVR rate with no effectiveness reduction in so called difficult\u2010to\u2010treat populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14936","type":"journal-article","created":{"date-parts":[[2019,11,17]],"date-time":"2019-11-17T03:44:23Z","timestamp":1573962263000},"page":"1238-1246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Real\u2010world experience with Grazoprevir\/Elbasvir in the treatment of previously \u201cdifficult to treat\u201d patients infected with hepatitis C virus genotype 1 and 4"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0938-1084","authenticated-orcid":false,"given":"Dorota","family":"Zar\u0119bska\u2010Michaluk","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Jan Kochanowski University  Kielce Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Jaroszewicz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Silesia  Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Buczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University Wroc\u0142a  Wroc\u0142aw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University Wroc\u0142a  Wroc\u0142aw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Lorenc","sequence":"additional","affiliation":[{"name":"Pomeranian Center of Infectious Diseases Medical University Gda\u0144sk  Gda\u0144sk Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Tudrujek\u2010Zdunek","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Medical University of Lublin  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Tomasiewicz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Medical University of Lublin  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Sitko","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases Jagiellonian University  Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksander","family":"Garlicki","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases Jagiellonian University  Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Janczewska","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, ID Clinic, Hepatology Outpatient Department, School of Public Health in Bytom Medical University of Silesia  Bytom Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Dybowska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology, Ludwik Rydygier Collegium Medicum in Bydgoszcz Faculty of Medicine Nicolaus Copernicus University  Toru\u0144 Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldemar","family":"Halota","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology, Ludwik Rydygier Collegium Medicum in Bydgoszcz Faculty of Medicine Nicolaus Copernicus University  Toru\u0144 Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Paw\u0142owska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology, Ludwik Rydygier Collegium Medicum in Bydgoszcz Faculty of Medicine Nicolaus Copernicus University  Toru\u0144 Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Pabjan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Jan Kochanowski University  Kielce Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W\u0142odzimierz","family":"Mazur","sequence":"additional","affiliation":[{"name":"Clinical Department of Infectious Diseases Medical University of Silesia  Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Czau\u017c\u2010Andrzejuk","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Bia\u0142ystok  Bia\u0142ystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Berak","sequence":"additional","affiliation":[{"name":"Hospital for Infectious Diseases in Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Horban","sequence":"additional","affiliation":[{"name":"Hospital for Infectious Diseases in Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"Socha","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hepatology and Liver Transplantation Pomeranian Medical University  Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Klapaczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Hepatology, Central Clinical Hospital of the Ministry of Internal Affairs and Administration  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Piekarska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of \u0141\u00f3d\u017a  \u0141\u00f3d\u017a Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Blaszkowska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Silesia  Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Belica\u2010Wdowik","sequence":"additional","affiliation":[{"name":"Regional Center for Diagnosis and Treatment of Viral Hepatitis and Hepatology  Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Dobracka","sequence":"additional","affiliation":[{"name":"MED.\u2010FIX  Wroc\u0142aw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Tronina","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine, Nephrology, and Internal Diseases Medical University of Warsaw  Warszawa Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbigniew","family":"Dero\u0144","sequence":"additional","affiliation":[{"name":"Ward of Infectious Diseases and Hepatology, Biega\u0144ski Regional Specialist Hospital  \u0141\u00f3d\u017a Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanta","family":"Bia\u0142kowska\u2010Warzecha","sequence":"additional","affiliation":[{"name":"Department of Infectious and Liver Diseases Medical University of \u0141\u00f3d\u017a  \u0141\u00f3d\u017a Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141ukasz","family":"Laurans","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hepatology and Liver Transplantation Pomeranian Medical University  Szczecin Poland"},{"name":"Multidisciplinary Regional Hospital  Gorz\u00f3w Wielkopolski Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Flisiak","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology Medical University of Bia\u0142ystok  Bia\u0142ystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"WHO Global Hepatitis Report2017 available from:https:\/\/www.who.int\/hepatitis\/publications\/global\u2010hepatitis\u2010report2017\/en\/(accessed on 21 September 2018)."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30181-9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2016.63871"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12861"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2015.06.002"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.53"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13626"},{"key":"e_1_2_5_9_1","unstructured":"Zepatier \u2010 Sumary of Product Characteristics"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2017.67782"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12801"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ722"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61795-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(14)61793-1","article-title":"Efficacy and safety of 8 weeks versus 12 weeks treatment with grazoprevir (MK\u20105172) and elbasvir (MK\u20108742) with or without ribavirin in patients with hepatitis C virus genotype 1 mono\u2010infection and HIV\/hepatitis C virus co\u2010infection (C\u2010Worthy): a randomized, open label phase 2 trial","author":"Sulkowski M","year":"2015","journal-title":"Lancet"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000007"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(15)00114-9"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00349-9"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-0785"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.09.045"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.04.009"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0010.7532"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13362"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1473-z"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0618-8278(19)30416-5"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0618-8278(19)30420-7"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0618-8278(19)30445-1"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0618-8278(19)30446-3"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13008"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14635"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1285-y"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S206938"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14447"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.10.003"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00813-17"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14509"},{"key":"e_1_2_5_37_1","first-page":"1026","article-title":"Grazoprevir\/elbasvir treatment for the relapse of HCV genotype 1b infection after ledipasvir\/sofosbuvir: a case report","volume":"16","author":"Tadokoro T","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4029541"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0739-8"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S133697"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.01.050"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13242"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.14936","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T13:44:22Z","timestamp":1694007862000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.14936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,16]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/jgh.14936"],"URL":"https:\/\/doi.org\/10.1111\/jgh.14936","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"type":"print","value":"0815-9319"},{"type":"electronic","value":"1440-1746"}],"subject":[],"published":{"date-parts":[[2020,1,16]]},"assertion":[{"value":"2019-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}