{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:44:34Z","timestamp":1785242674212,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>There is little published research to examine the best approach to the management of <jats:italic>Helicobacter pylori<\/jats:italic> in Myanmar. This study aimed to determine the relative efficacy and tolerability of sequential eradication therapy compared to Myanmar's current recommendation of a concomitant four drug regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were screened for <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content> using monoclonal Stool Antigen Testing (SAT). Those testing positive were randomized 1:1 to receive receive Myanmar's first\u2010line regimen of 14\u00a0days of concomitant rabeprazole, clarithromycin, amoxycillin and tinidazole (140 pills, cost US$23) or 10\u00a0days of sequential rabeprazole, clarithromycin, amoxycillin and tinidazole (60 pills, cost US$10). Adherence and adverse effects were recorded, and the efficacy of the regimens assessed with repeat SAT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1011 patients screened for H. pylori infection, 313 (31%) tested positive. There was no statistical difference in the cure rates of the two regimens in either intention\u2010to\u2010treat: 128\/157 (82%; 95% confidence interval (CI): 75\u201387%) receiving sequential therapy versus 123\/156 (79%; 95% CI: 72\u201385%) receiving concomitant therapy (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.55) or per\u2010protocol analysis: 125\/131 (95%; 95% CI: 90\u201398) receiving sequential therapy versus 121\/130 (93%; 95% CI: 87\u201396) receiving concomitant therapy (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.42). Side effects of therapy were reported in 54\/157 (47%) patients taking sequential therapy compared with 62\/156 (53%) taking concomitant therapy, but this difference did not reach statistical significance (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.33).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this high\u2010burden, resource\u2010poor setting, less expensive sequential therapy was as effective and as well tolerated as the currently recommended concomitant four drug regimen for eradication of <jats:styled-content style=\"fixed-case\"><jats:italic>H. pylori<\/jats:italic><\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14942","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T09:53:09Z","timestamp":1574502789000},"page":"617-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sequential <i>Helicobacter pylori<\/i> eradication therapy in Myanmar; a randomized clinical trial of efficacy and tolerability"],"prefix":"10.1111","volume":"35","author":[{"given":"Nan Phyu Sin Toe","family":"Myint","sequence":"first","affiliation":[{"name":"Insein General Hospital, Insein Township  Yangon Myanmar"},{"name":"University of Medicine 2  North Okkalapa Township Yangon Myanmar"},{"name":"Myanmar Australia Research Collaboration for Health (MARCH)  Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thet Tun","family":"Zaw","sequence":"additional","affiliation":[{"name":"Insein General Hospital, Insein Township  Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyauk","family":"Sain","sequence":"additional","affiliation":[{"name":"Insein General Hospital, Insein Township  Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soe","family":"Waiyan","sequence":"additional","affiliation":[{"name":"Insein General Hospital, Insein Township  Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-6811","authenticated-orcid":false,"given":"Mark","family":"Danta","sequence":"additional","affiliation":[{"name":"St Vincent's Clinical School, Faculty of Medicine University of New South Wales  Kensington Sydney Australia"},{"name":"Department of Gastroenterology St Vincent's Hospital  Darlinghurst Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cooper","sequence":"additional","affiliation":[{"name":"Myanmar Australia Research Collaboration for Health (MARCH)  Yangon Myanmar"},{"name":"Kirby Institute University of New South Wales  Kensington Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ne Myo","family":"Aung","sequence":"additional","affiliation":[{"name":"Insein General Hospital, Insein Township  Yangon Myanmar"},{"name":"University of Medicine 2  North Okkalapa Township Yangon Myanmar"},{"name":"Myanmar Australia Research Collaboration for Health (MARCH)  Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar Mar","family":"Kyi","sequence":"additional","affiliation":[{"name":"Insein General Hospital, Insein Township  Yangon Myanmar"},{"name":"University of Medicine 2  North Okkalapa Township Yangon Myanmar"},{"name":"Myanmar Australia Research Collaboration for Health (MARCH)  Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1423-3839","authenticated-orcid":false,"given":"Josh","family":"Hanson","sequence":"additional","affiliation":[{"name":"University of Medicine 2  North Okkalapa Township Yangon Myanmar"},{"name":"Myanmar Australia Research Collaboration for Health (MARCH)  Yangon Myanmar"},{"name":"Kirby Institute University of New South Wales  Kensington Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i2.629"},{"key":"e_1_2_6_3_1","first-page":"17","article-title":"H. pylori infection among Buddhist monks in the selected regions of Myanmar","volume":"57","author":"Aye TT","year":"2015","journal-title":"Myanmar Med. 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