{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:21:52Z","timestamp":1770412912083,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 108 P07"],"award-info":[{"award-number":["NTUH 108 P07"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>We elucidated the clinical significance of distal contractile integral\u2010to\u2010esophageal impedance integral (EII) ratio (DCIIR) in ineffective esophageal motility (IEM) adult patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 101 patients with IEM (48.38\u00a0\u00b1\u00a01.58\u00a0years) and 42 matched healthy volunteers (44.28\u00a0\u00b1\u00a01.85\u00a0years) in this case\u2013control study. All subjects underwent esophageal high\u2010resolution impedance manometry from October 2014 to May 2018. The diagnosis of IEM was based on the Chicago Classification version 3.0. The EII, EII ratio, and DCIIR were analyzed by <jats:sc>matlab<\/jats:sc> software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The EII, EII ratio, and DCIIR calculated at an impedance threshold of 1500\u00a0\u03a9 (EII1500, EII ratio1500, and DCIIR1500, respectively) were significantly lower in the IEM group than in healthy controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001, &lt;\u00a00.0001, and &lt;\u00a00.0001, respectively). Receiver operating characteristic analysis showed that DCIIR1500\u00a0&lt;\u00a00.008\u00a0mmHg\/\u03a9, EII1500\u00a0&gt;\u00a071\u00a0000\u00a0\u03a9.s.cm, and EII ratio1500 &gt;\u00a00.43 were all predictive of IEM. Only DCIIR1500\u00a0&lt;\u00a00.008\u00a0mmHg\/\u03a9 remained significant in diagnosing IEM in the multivariate logistic regression analysis (odds ratio\u00a0=\u00a072.13, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The DCIIR1500 is negatively correlated with Eckardt score and the Reflux Disease Questionnaire (correlation coefficient\u00a0=\u00a0\u22120.2844 and \u22120.3136; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0006 and 0.0002, respectively). Receiver operating characteristic analysis further showed that a DCIIR1500 cut\u2010off of 0.002\u00a0mmHg\/\u03a9 achieved the best differentiation between the IEM\u2010alternans and IEM\u2010persistens subtypes among IEM patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel pressure\u2013impedance parameter of high\u2010resolution impedance manometry, DCIIR1500, may assist in the diagnosis and classification of IEM and correlated with clinical symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14981","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:43:37Z","timestamp":1578876217000},"page":"1317-1324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pressure\u2013impedance analysis: Assist the diagnosis and classification of ineffective esophageal motility disorder"],"prefix":"10.1111","volume":"35","author":[{"given":"Jia\u2010Feng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u2010Jung","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu\u2010Wei","family":"Tong","sequence":"additional","affiliation":[{"name":"Graduate Institute of Electronics Engineering National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Cheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Electronics Engineering National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Hsiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Electronics Engineering National Taiwan University  Taipei Taiwan"},{"name":"Department of Electrical Engineering National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-7538","authenticated-orcid":false,"given":"Ping\u2010Huei","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei 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