{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:11:48Z","timestamp":1788336708295,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T00:00:00Z","timestamp":1580774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00079"],"award-info":[{"award-number":["PI18\/00079"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Accurate information on the epidemiology of hepatitis C and B infection is mandatory to establish a national\/regional plan. We aim to update the prevalence of hepatitis C and B infection in Catalonia using point\u2010of\u2010care tests to analyze the risk factors related and to implement a linkage\u2010to\u2010care circuit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a community\u2010based study. A random list of adult individuals was retrieved from censuses of primary care centers. Point\u2010of\u2010care tests for anti\u2010hepatitis C virus (HCV) and HBV surface antigen (HBsAg) and a questionnaire for risk factor assessment were performed. Positive results were validated and a circuit for linkage\u2010to\u2010care was established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3328 individuals were included. The anti\u2010HCV and HBsAg overall prevalence were lower than expected [1.02%, 95% confidence interval (CI) 0.65\u20131.39; and 0.52%, 95% CI 0.26\u20130.77, respectively]. Anti\u2010HCV positive subjects were mostly (88%) autochthonous. The prevalence increased with age; only 12% were under age 40. The associated risk factors were drug use, blood transfusion, relative with HCV, and diabetes. Notably, the prevalence of active infection was only 0.49% (95% CI 0.23\u20130.74), 40% less than previously reported, reflecting the impact of direct acting antiviral therapy. Differently, HBsAg positive subjects were mostly foreign migrants (53%) with no other risk factors. Despite the implementation of a linkage\u2010to\u2010care circuit, one third of HBsAg positive subjects were lost.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of HCV infection was lower than previously reported, showing a strong impact of direct acting antiviral therapy in the last years. Because of hepatitis B universal vaccination, HBV infection in Catalonia is mainly associated with migrant population. Linkage\u2010to\u2010care in patients with hepatitis B was challenging and warrants additional efforts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.14984","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T11:20:12Z","timestamp":1579519212000},"page":"1570-1578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Significant decrease in the prevalence of hepatitis C infection after the introduction of direct acting antivirals"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3189-7557","authenticated-orcid":false,"given":"Sergio","family":"Rodr\u00edguez\u2010Tajes","sequence":"first","affiliation":[{"name":"Liver Unit, Hospital Cl\u00ednic, IDIBAPS and CIBEREHD University of Barcelona  Barcelona Spain"},{"name":"Societat Catalana de Digestologia  Barcelona 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