{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:10:50Z","timestamp":1787015450412,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>The incidence of mortality and hepatocellular carcinoma (HCC) in patients with non\u2010alcoholic fatty liver disease (NAFLD) has been reported, but the long\u2010term outcomes of Japanese patients with NAFLD are not fully evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We enrolled 365 Japanese patients with biopsy\u2010confirmed NAFLD (1990\u20132008) followed for \u2265\u00a06\u00a0months: 185 males (50.7%); median age (54\u00a0years); advanced fibrosis 108 (29.8%); HCC,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a026 (7.1%); diabetes,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0191 (52.3%); dyslipidemia,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0234 (64.1%); and hypertension,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0193 (52.9%). We analyzed the survival and new\u2010onset HCC rates for hepatic fibrosis as well as complications and the treatment of lifestyle\u2010related diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the median 7.1\u2010year follow\u2010up, 44 patients (12.1%) died:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a028 liver\u2010related (10\u00a0years liver\u2010related death, 9.4%) and\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a016 non\u2010liver\u2010related deaths (10\u00a0years non\u2010liver\u2010related death, 4.9%). Both incidence rates were significantly higher in the advanced fibrosis group. The incidence of HCC at 10\u00a0years was 20.1% in the advanced fibrosis group, and the mortality was increased in patients with higher age, history of HCC, lower seru\\m level of albumin, higher level of \u03b3\u2010glutamyltransferase, and insulin treatment for diabetes. Risk factors for HCC onset were higher levels of aspartate aminotransferase and triglyceride and hypertension treatment. Platelet count &lt;\u00a011.5\u00a0\u00d7\u00a010\n                      <jats:sup>4<\/jats:sup>\n                      \/\u03bcL was revealed as a risk factor for death and HCC development.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The rates of both liver\u2010related and non\u2010liver\u2010related deaths and HCC development were significantly prominent in the patients with advanced fibrosis. It is important to identify and treat NAFLD patients who have several risk factors and advanced fibrosis, which might be predicable simply by the platelet count.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.14989","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T02:10:38Z","timestamp":1579831838000},"page":"1579-1589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Long\u2010term outcomes of non\u2010alcoholic fatty liver disease and the risk factors for mortality and hepatocellular carcinoma in a Japanese population"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1248-4324","authenticated-orcid":false,"given":"Tomomi","family":"Kogiso","sequence":"first","affiliation":[{"name":"Institute of Gastroenterology, Department of Internal Medicine Tokyo Women's Medical University  Tokyo 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