{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:35:40Z","timestamp":1791898540128,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T00:00:00Z","timestamp":1581638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NTU\u2010107L9014\u20101"],"award-info":[{"award-number":["NTU\u2010107L9014\u20101"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW107\u2010TDU\u2010B\u2010211\u2010123002"],"award-info":[{"award-number":["MOHW107\u2010TDU\u2010B\u2010211\u2010123002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["TCTC 108\u20102321\u2010B\u2010002\u2010040"],"award-info":[{"award-number":["TCTC 108\u20102321\u2010B\u2010002\u2010040"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 108\u20102314\u2010B\u2010002\u2010187"],"award-info":[{"award-number":["MOST 108\u20102314\u2010B\u2010002\u2010187"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 108\u20102314\u2010B\u2010002\u2010209"],"award-info":[{"award-number":["MOST 108\u20102314\u2010B\u2010002\u2010209"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 106\u2010P06"],"award-info":[{"award-number":["NTUH 106\u2010P06"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 107\u2010P05"],"award-info":[{"award-number":["NTUH 107\u2010P05"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The rising prevalence of antibiotic resistance and the long\u2010term safety following eradication therapy are important issues in the management of <jats:italic>Helicobacter pylori<\/jats:italic> infection. The prevalence of clarithromycin, levofloxacin, and metronidazole resistance of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> has increased to 21%, 27%, and 45%, respectively, in the Asia\u2010Pacific region. Personalized treatment guided by susceptibility testing may provide a reliably excellent eradication rate in the first\u2010line treatment but is costly and not widely available. Population\u2010specific empirical therapy according to the local prevalence of antibiotic resistance may be an alternative strategy. Levofloxacin\u2010based therapy and bismuth quadruple therapy are the recommended second\u2010line rescue therapy. Susceptibility testing or genotypic resistance\u2010guided therapy is the preferred treatment for refractory <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> infection, but empirical therapy may be an acceptable alternative. Eradication of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> leads to short\u2010term perturbation of gut microbiota. The diversity of gut microbiota can be restored months after eradication therapy, but the speed of recovery varies with regimens. The short\u2010term increases of antibiotic resistance of <jats:styled-content style=\"fixed-case\"><jats:italic>Escherichia coli<\/jats:italic><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:italic>Klebsiella pneumoniae<\/jats:italic><\/jats:styled-content> may be restored to basal states months after <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication. Future studies that apply in\u2010depth sequencing, such as shotgun metagenomics sequencing, are needed to clarify whether the compositions of gut microbiota at the species level are fully restored.<\/jats:p>","DOI":"10.1111\/jgh.14992","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T01:34:41Z","timestamp":1580088881000},"page":"1107-1116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Treatment of <i>Helicobacter pylori<\/i> infection and its long\u2010term impacts on gut microbiota"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7945-5408","authenticated-orcid":false,"given":"Jyh\u2010Ming","family":"Liou","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Cancer Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-1216","authenticated-orcid":false,"given":"Yi\u2010Chia","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1940-6428","authenticated-orcid":false,"given":"Ming\u2010Shiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708423"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.01.028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji277"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11050593"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30219-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.198309"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61579-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310142"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31409-X"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky183"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.439"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr217"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks407"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.06.047"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.195"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad9358"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-6-200309160-00011"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.040"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.563"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.006"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05211.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311304"},{"key":"e_1_2_8_25_1","first-page":"CD008337","article-title":"Optimum duration of regimens for Helicobacter pylori eradication","volume":"12","author":"Yuan Y","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13495"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13069"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0217-2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00033-06"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12554"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9781212"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14456"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12495"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00140-17"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311868"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15273"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv155"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12654"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-018-0471-z"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302254"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124199"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13712"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X15621229"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01131-10"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312297"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10410"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.001"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44935"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30272-5"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009836"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151893"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12270"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2017-000182"},{"key":"e_1_2_8_54_1","first-page":"S2352\u20133964(18)3","article-title":"The impact of Helicobacter pylori infection, eradication therapy and probiotic supplementation on gut microenvironment homeostasis: an open\u2010label, randomized clinical trial","author":"Chen L","year":"2018","journal-title":"EBioMedicine"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12541"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12498"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14736"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.09.010"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213548"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01902"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540701299608"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.14992","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.14992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T13:44:06Z","timestamp":1694007846000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.14992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,14]]},"references-count":60,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/jgh.14992"],"URL":"https:\/\/doi.org\/10.1111\/jgh.14992","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,14]]},"assertion":[{"value":"2019-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}