{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:51:37Z","timestamp":1783075897038,"version":"3.54.6"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,2,23]],"date-time":"2020-02-23T00:00:00Z","timestamp":1582416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670788"],"award-info":[{"award-number":["81670788"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is a growing public health concern worldwide. With the progression of urbanization, light pollution is becoming an inevitable risk factor for NAFLD. However, the role of light pollution on NAFLD is insufficiently understood, and the underlying mechanism remains unclear. The present study explored effects of constant light exposure on NAFLD and elucidated its related mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two male Sprague Dawley rats were divided into four groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a08 each): (i) rats on a normal diet exposed to standard light\u2013dark cycle (ND\u2010LD); (ii) rats on a normal diet exposed to constant light (ND\u2010LL); (iii) rats on a high\u2010fat diet exposed to standard light\u2013dark cycle (HFD\u2010LD); and (iv) and rats on a high\u2010fat diet exposed to constant light (HFD\u2010LL). After 12\u00a0weeks of treatment, rats were sacrificed and pathophysiological assessments were performed. Targeted lipidomics was used to measure sphingolipids, including ceramides, glucosylceramides, and lactosylceramides, sphingomyelins, and sphingosine\u20101\u2010phosphates in plasma and liver tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In normal chow rats, constant light exposure led to glucose abnormalities and dyslipidemia. In high\u2010fat\u2010fed rats, constant light exposure exacerbated glucose abnormalities, dyslipidemia, insulin resistance, and inflammation and aggravated steatohepatitis. Compared with HFD\u2010LD rats, HFD\u2010LL had decreased plasma sphingosine\u20101\u2010phosphate and elevated liver concentrations of total ceramide and specific ceramide species (ceramide d18:0\/24:0, ceramide d18:1\/22:0, ceramide d18:1\/24:0, and ceramide d18:1\/24:1), which were associated with increased hepatocyte apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Constant light exposure causes dysregulation of sphingolipids and promotes steatohepatitis in high\u2010fat\u2010fed rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15005","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T15:31:53Z","timestamp":1581003113000},"page":"1978-1989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of constant light exposure on sphingolipidomics and progression of NASH in high\u2010fat\u2010fed rats"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8124-7261","authenticated-orcid":false,"given":"Fangzhi","family":"Yue","sequence":"first","affiliation":[{"name":"Department of Endocrinology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin Man","family":"Lam","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghou","family":"Shui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwei","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Health and Human Performance, College of Health Professions University of Texas Rio Grande Valley  Brownsville Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.07.033"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1590"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12688"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9023027"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.08.029"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.07.056"},{"key":"e_1_2_6_8_1","first-page":"1","article-title":"Systematic review of light exposure impact on human circadian rhythm","volume":"36","author":"T\u00e4hk\u00e4m\u00f6 L","year":"2018","journal-title":"Chronobiol. 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