{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:58:07Z","timestamp":1790873887155,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The prognosis of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is very poor. This study aimed to evaluate hepatic arterial infusion chemotherapy (HAIC) <jats:italic>versus<\/jats:italic> sorafenib (SORF) in the treatment of HCC with PVTT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Studies were identified online in Embase and MEDLINE before October 31, 2019. The end\u2010points were overall survival (OS), progression\u2010free survival (PFS), disease control rate (DCR), and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six studies with 417 cases were included in this systematic review. Meta\u2010analyses demonstrated that HAIC is superior to SORF with respect to OS (hazard ratio [HR]: 0.50, 95% confidence interval: 0.38\u20130.66, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and PFS (HR: 0.47, 95% confidence interval: 0.31\u20130.73, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) irrespective of research territoriality and study quality. Our systematic review also demonstrated that HAIC is superior to SORF with respect to DCR. Subgroup analysis demonstrated that the advantage is more obvious in the treatment of types III\u2013IV PVTT with respect to OS (HR: 0.29, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and PFS(HR: 0.39, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). HAIC caused more grades 3\u20134 neutropenia (HR: 10.71), anemia (HR: 7.55), leukopenia (HR: 10.38), and thrombocytopenia (HR: 13.09) than SORF. However, HAIC caused fewer cases of grades 3\u20134 aspartate aminotransferase rising (HR: 0.21), diarrhea (HR: 0.14), and hand\u2010foot syndrome (HR: 0.14) than SORF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This systematic review demonstrated that HAIC is superior to SORF in HCC with PVTT with respect to OS, PFS, and DCR, especially in HCC with types III\u2013IV PVTT. HAIC caused more myelosuppression, whereas SORF is associated with diarrhea and hand\u2010foot syndrome. Further randomized controlled trials are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15010","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T12:29:26Z","timestamp":1581596966000},"page":"1277-1287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Systematic review of hepatic arterial infusion chemotherapy <i>versus<\/i> sorafenib in patients with hepatocellular carcinoma with portal vein tumor thrombosis"],"prefix":"10.1111","volume":"35","author":[{"given":"Miao","family":"Liu","sequence":"first","affiliation":[{"name":"Gastrointestinal Tumor Center Chongqing University Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Chongqing Medical University  Chongqing 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