{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:10:22Z","timestamp":1791637822025,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2019\u2010838"],"award-info":[{"award-number":["2019\u2010838"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>The purpose of this study was to investigate the long\u2010term oncologic outcomes after stereotactic body radiation therapy (SBRT) for small hepatocellular carcinoma (HCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 290 patients with HCC were registered between March 2007 and July 2013. A dose of 10\u201315\u00a0Gy per fraction was given over three to four consecutive days, resulting in a total dose of 30\u201360\u00a0Gy. Overall and recurrence\u2010free survivals were estimated from the date of the start of SBRT to the date of death, the last follow\u2010up examination, or to the date of tumor recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median follow\u2010up period of all patients was 38.2\u00a0months, and the median tumor size was 1.7\u00a0cm. Overall survival (OS) rate at 5\u00a0years was 44.9%. Multivariate analyses revealed that age, Child\u2013Pugh class, tumor size, and albumin levels were significant factors for OS. The 5\u2010year local control rate was 91.3%. In multivariate analysis, tumor size and albumin were significantly associated with local tumor control. However, there was a negative correlation between total dose and tumor size in Pearson's correlation analysis (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.111,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.046).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Stereotactic body radiation therapy was an excellent ablative treatment option for patients with small HCC. Tumor size was a significant factor for local tumor control after SBRT, although the total dose was negatively correlated with tumor size. Considering the low OS rates and the high local tumor control rates, the combined SBRT and systemic therapies may be beneficial for improving survival outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.15011","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T08:09:16Z","timestamp":1581581356000},"page":"1953-1959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Clinical outcomes of stereotactic body radiation therapy for small hepatocellular carcinoma"],"prefix":"10.1111","volume":"35","author":[{"given":"Sunmin","family":"Park","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Department of Radiation Oncology Korea University Ansan Hospital  Ansan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byungchul","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Cheol","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Suk","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7631-4124","authenticated-orcid":false,"given":"Han Chu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongmoo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of 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