{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:45:22Z","timestamp":1773675922296,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2011\u20100030001"],"award-info":[{"award-number":["2011\u20100030001"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Few studies have evaluated the change in serum pepsinogen (sPG) levels after the eradication of <jats:italic>Helicobacter pylori<\/jats:italic>. The aim of this study was to evaluate the effect of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication on sPG levels in patients with gastric cancer\/dysplasia in comparison to a control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled 368 patients with gastric cancer\/dysplasia and 610 control subjects. <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> status and sPG levels were measured before and after eradication. The follow\u2010up time points were classified as &lt;\u00a012, 12\u201323, 24\u201335, and \u2265\u00a036\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 179 <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content>\u2010eradicated patients with gastric cancer\/dysplasia and 168 control group subjects, sPG I significantly decreased, and the sPG I\/II ratio significantly increased after eradication compared to baseline, and this improvement in sPG values was maintained during all follow\u2010up time points. Significant differences in sPG I and the sPG I\/II ratio were observed between the gastric cancer\/dysplasia group and the control group &lt;\u00a024\u00a0months after eradication. However, these differences in sPG values disappeared after \u2265\u00a024\u00a0months of follow up. Moreover, significant differences in the intestinal metaplasia grade were observed between these two groups before eradication until &lt;\u00a024\u00a0months after eradication. However, these differences in the intestinal metaplasia grade disappeared after \u2265\u00a024\u00a0months of follow up in the corpus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The sPG values and intestinal metaplasia grade (corpus) in the gastric cancer\/dysplasia group became similar to those in the control group at long\u2010term follow up after <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication. It might be related with the reduction of metachronous gastric neoplasm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15017","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T02:59:25Z","timestamp":1582513165000},"page":"1540-1548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010term follow up of serum pepsinogens in patients with gastric cancer or dysplasia after <i>Helicobacter pylori<\/i> eradication"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3805-4835","authenticated-orcid":false,"given":"Gitark","family":"Noh","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine Seoul National University Bundang Hospital  Seongnam South 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