{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:44:03Z","timestamp":1788414243636,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T00:00:00Z","timestamp":1584144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aim<\/jats:title><jats:p>Bariatric surgery is a valid treatment option for persons with non\u2010alcoholic fatty liver disease. This study prospectively examined the impact of laparoscopic sleeve gastrectomy (LSG) on liver histopathology, and blood levels of adiponectin, leptin, resistin, and pre\u2010B cell enhancing factor\/Nampt\/visfatin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients &amp; Methods<\/jats:title><jats:p>In 81 patients with non\u2010alcoholic fatty liver disease who underwent LSG, paired liver biopsies and blood specimens were obtained before and 18\u00a0months after LSG. Differences between preoperative and 18\u00a0months postoperative data were tested by paired Student's <jats:italic>t<\/jats:italic>\u2010test or Wilcoxon rank test as appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At follow up, there was a significant improvement in biochemical markers for glucose homeostasis, including fasting glucose, HbA1c, insulin levels, and homeostatic model assessment index. Postoperative liver function tests, namely serum alanine aminotransferase, aspartate aminotransferase, and gamma\u2010glutamyl transpeptidase level, showed a significant improvement compared to before weight loss. The number of patients who had definite, borderline, or no non\u2010alcoholic steatohepatitis was 43 (53%), 27 (33%), and 11 (14%), respectively, at baseline, and 9 (11%), 32 (40%), and 40 (49%) at 18\u2010month post\u2010surgery follow up. A significant reduction in steatosis, liver fibrosis, lobular inflammation, and hepatocyte ballooning was observed in the postoperative biopsies (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 each). In addition, at the follow\u2010up assessment, there was a significant increase in serum adiponectin levels and significant decline in serum levels of leptin, resisitin, and pre\u2010B cell enhancing factor\/Nampt\/visfatin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Weight loss after sleeve gastrectomy was associated with a significant improvement in several metabolic parameters, liver enzyme levels, liver histopathology, and changes in serum adipokine levels towards antidiabetic and anti\u2010inflammatory profiles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15029","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T06:44:48Z","timestamp":1583822688000},"page":"1769-1773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Effect of weight loss induced by laparoscopic sleeve gastrectomy on liver histology and serum adipokine levels"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0026-0841","authenticated-orcid":false,"given":"Ahmed Abdallah","family":"Salman","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Faculty of medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1097-2615","authenticated-orcid":false,"given":"Ahmed Abd El Aal","family":"Sultan","sequence":"additional","affiliation":[{"name":"General Surgery Department, Faculty of medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abdallah","sequence":"additional","affiliation":[{"name":"General Surgery Department, Faculty of medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abdelsalam","sequence":"additional","affiliation":[{"name":"General Surgery Department, 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