{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:43:53Z","timestamp":1792511033728,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The presence and severity of upper gastrointestinal mucosal lesions have not been evaluated using esophagogastroduodenoscopy (EGD) in patients receiving ticagrelor plus aspirin or alone after myocardial revascularization. We assessed upper gastrointestinal mucosal injury and the use of proton pump inhibitors (PPIs) in patients receiving 1\u00a0year of antiplatelet therapy after coronary artery bypass grafting (CABG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010center prospective substudy of a randomized trial, 231 patients completing 1\u2010year antiplatelet therapy (ticagrelor 90\u00a0mg twice daily plus aspirin 100\u00a0mg once daily, ticagrelor 90\u00a0mg twice daily, or aspirin 100\u00a0mg once daily, in 81, 80, and 70 patients, respectively) after CABG underwent <jats:sup>13<\/jats:sup>C urea breath testing and EGD. Gastroduodenal lesions were assessed by modified Lanza score, and reflux esophagitis was evaluated according to Los Angeles classification. Additionally, at least one ulcer \u2265\u00a05\u00a0mm was separately analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 231 patients, EGD showed 28 (12.1%) with ulcers \u2265\u00a05\u00a0mm, which were detected in 13.6% (11\/81) of ticagrelor plus aspirin recipients, 8.8% (7\/80) of ticagrelor recipients, and 14.3% (10\/70) of aspirin recipients, and 24 (10.4%) had reflux esophagitis. Eighty\u2010eight (38.1%) patients had a positive <jats:sup>13<\/jats:sup>C urea breath testing after 1\u00a0year of treatment, and one patient received eradication therapy during follow up. Nineteen (8.2%) patients received a PPI for \u2265\u00a06\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severe upper gastrointestinal mucosal lesions were more frequently observed in patients treated with ticagrelor plus aspirin and aspirin monotherapy than in patients treated with ticagrelor monotherapy for 1\u00a0year post\u2010CABG. Prophylactic use of PPIs might be inadequate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15030","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T14:17:11Z","timestamp":1583849831000},"page":"1720-1730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Upper gastrointestinal mucosal injury associated with ticagrelor plus aspirin, ticagrelor alone, or aspirin alone at 1\u2010year after coronary artery bypass grafting"],"prefix":"10.1111","volume":"35","author":[{"given":"Chenyue","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3544-8820","authenticated-orcid":false,"given":"Lifen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000182"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv320"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.513"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx419"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000558"},{"key":"e_1_2_6_7_1","unstructured":"22nd China Cardiovascular Intervention Forum.International circulation. 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