{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:35:10Z","timestamp":1762868110723,"version":"3.40.5"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1D1A1B03031483"],"award-info":[{"award-number":["2017R1D1A1B03031483"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) may reduce the risk of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB). However, it is not clear whether there is difference in the on\u2010treatment HCC risks between ETV and TDF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective cohort study, we compared the on\u2010treatment HCC incidence of ETV and TDF in 1340 consecutive nucleos(t)ide analog\u2010na\u00efve CHB patients by propensity score (PS) matching analysis. PS was calculated by using age, sex, drinking history, diabetes, liver cirrhosis, hepatitis B e antigen positivity, hepatitis B virus DNA, hepatitis B s antigen titer, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alpha\u2010fetoprotein, albumin, bilirubin, prothrombin time, platelet count, and calendar year of treatment initiation as covariates. The HCC risk was assessed by Cox regression with death and liver transplantation as competing risks in the 1:1 PS\u2010matched cohorts (<jats:italic>n<\/jats:italic>\u00a0=\u00a0596).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TDF had higher cumulative virologic response (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.027) whereas ETV showed higher AST and ALT normalization rates (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005 and\u00a0&lt;\u00a00.001, respectively) in PS\u2010matched cohorts. HCC risk was similar between ETV and TDF, either by PS\u2010matching analysis (hazard ratio [HR] for TDF over ETV\u00a0=\u00a02.06, 95% confidence interval [CI]\u00a0=\u00a00.98\u20134.33, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.058) or inverse probability of treatment weighting analysis (HR\u00a0=\u00a01.30, 95% CI\u00a0=\u00a00.81\u20132.10; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.276).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ETV and TDF treatment was associated with similar risk for HCC development in CHB patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15031","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T15:28:11Z","timestamp":1583854091000},"page":"1774-1781","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of the on\u2010treatment risks for hepatocellular carcinoma between entecavir and tenofovir: A propensity score matching analysis"],"prefix":"10.1111","volume":"35","author":[{"given":"Ingyoon","family":"Ha","sequence":"first","affiliation":[{"name":"Department of Medicine Seoul National University Bundang Hospital  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Wha","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Medicine Seoul National University Bundang Hospital  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4274-2582","authenticated-orcid":false,"given":"Eun Sun","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Medicine Seoul National University Bundang Hospital  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-7990","authenticated-orcid":false,"given":"Sook\u2010Hyang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Medicine Seoul National University Bundang Hospital  Seongnam Republic of Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0934-3344","authenticated-orcid":false,"given":"Jin\u2010Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine Seoul National University Bundang Hospital  Seongnam Republic of Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.35"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32152-9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61425-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033364"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26180"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.257"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29537"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13253"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306409"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013983"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.02.033"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29320"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2017.02.001"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.03.028"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4070"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.09.025"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.3.314"},{"key":"e_1_2_5_19_1","first-page":"90","article-title":"Observational studies: propensity score analysis of non\u2010randomized data","volume":"16","author":"Trojano M","year":"2009","journal-title":"Int. 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