{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:09:03Z","timestamp":1790611743825,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["VGHKS105\u2010081"],"award-info":[{"award-number":["VGHKS105\u2010081"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Concomitant therapy is a recommended first\u2010line treatment for <jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> infection in most national or international consensuses. Reverse hybrid therapy is a modified 14\u2010day concomitant therapy without clarithromycin and metronidazole in the final 7\u00a0days. This study aims to test whether 14\u2010day reverse hybrid therapy is non\u2010inferior to 14\u2010day concomitant therapy in the first\u2010line treatment of <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content>\u2010infected adult patients were randomly assigned to receive either reverse hybrid therapy (dexlansoprazole 60\u00a0mg o.d. plus amoxicillin 1\u00a0g b.d. for 14\u00a0days, and clarithromycin 500\u00a0mg plus metronidazole 500\u00a0mg b.d. for initial 7\u00a0days) or concomitant therapy (dexlansoprazole 60\u00a0mg once o.d. plus amoxicillin 1\u00a0g, clarithromycin 500\u00a0mg, and metronidazole 500\u00a0mg b.d. for 14\u00a0days). <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> status was assessed 6\u00a0weeks after the end of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content>\u2010infected participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a0248) were randomized to receive either 14\u2010day reverse hybrid therapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a0124) or 14\u2010day concomitant therapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a0124). Intention\u2010to\u2010treat analysis demonstrated that the two therapies had comparable eradication rate (95.2% <jats:italic>vs<\/jats:italic> 93.5%; 95% confidence interval, \u22124.0% to 7.4%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.582). However, reverse hybrid therapy had a much lower frequency of adverse events than concomitant therapy (20.2% <jats:italic>vs<\/jats:italic> 38.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). The two therapies exhibited comparable drug adherence (93.5% <jats:italic>vs<\/jats:italic> 87.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.125).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fourteen\u2010day reverse hybrid therapy and 14\u2010day concomitant therapy are equivalent in efficacy for the first\u2010line treatment of <jats:italic>H.\u00a0pylori<\/jats:italic> infection. However, reverse hybrid therapy has fewer adverse events compared with concomitant therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15034","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T13:39:00Z","timestamp":1584106740000},"page":"1731-1737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Equivalent efficacies of reverse hybrid and concomitant therapies in first\u2010line treatment of <scp><i>Helicobacter pylori<\/i><\/scp> infection"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3905-4674","authenticated-orcid":false,"given":"Ping\u2010I","family":"Hsu","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine An Nan Hospital, China Medical University  Tainan 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Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzung\u2010Jiun","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaohsiung Veterans General Hospital and National Yang\u2010Ming University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Hung","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kaohsiung Municipal Siaogang\u00a0Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Shuo","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaohsiung Veterans General Hospital and National Yang\u2010Ming University  Kaohsiung 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