{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:25:14Z","timestamp":1791001514055,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Mochida Pharmaceutical Co., Ltd."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      5\u2010Aminosalicylic acid (5\u2010ASA) is a fundamental treatment for mild\u2010to\u2010moderate ulcerative colitis (UC). 5\u2010ASA is taken up into the colonic mucosa and metabolized to\n                      <jats:italic>N<\/jats:italic>\n                      \u2010acetyl\u20105\u2010ASA (Ac\u20105\u2010ASA). Few studies have assessed whether mucosal 5\u2010ASA and Ac\u20105\u2010ASA concentrations are associated with endoscopic remission. This study aimed to investigate differences in 5\u2010ASA and Ac\u20105\u2010ASA concentrations according to endoscopic activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center, prospective, cross\u2010sectional study was conducted between March 2018 and February 2019. UC patients who were administered with 5\u2010ASA medication for at least 8\u00a0weeks before sigmoidoscopy were enrolled. Mucosal 5\u2010ASA and Ac\u20105\u2010ASA concentrations were measured using liquid chromatography with tandem mass spectrometry. The primary endpoint was defined as the difference in mucosal concentrations of 5\u2010ASA and Ac\u20105\u2010ASA, according to the Mayo endoscopic subscore (MES).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mucosal concentrations were analyzed in 50 patients. In the sigmoid colon, the median 5\u2010ASA concentration in patients with MES of 0 (17.3\u00a0ng\/mg) was significantly higher than MES\u00a0\u2265\u00a01 (6.4\u00a0ng\/mg) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.019). The median 5\u2010ASA concentrations in patients with Ulcerative Colitis Endoscopic Index of Severity\u00a0\u2264\u00a01 (16.4\u00a0ng\/mg) were also significantly higher than in patients with Ulcerative Colitis Endoscopic Index of Severity\u00a0\u2265\u00a02 (4.63\u00a0ng\/mg) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.047). In the sigmoid colon, the concentration of Ac\u20105\u2010ASA was higher in patients with MES of 0 (21.2\u00a0ng\/mg) than in patients with MES\u00a0\u2265\u00a01 (5.81\u00a0ng\/mg) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.022).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study showed that mucosal Ac\u20105\u2010ASA concentrations, as well as 5\u2010ASA concentrations, are higher in UC patients with endoscopic remission. Ac\u20105\u2010ASA may be useful for a biomarker of 5\u2010ASA efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.15059","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T11:37:13Z","timestamp":1586173033000},"page":"1878-1885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mucosal concentrations of\n                    <i>N<\/i>\n                    \u2010acetyl\u20105\u2010aminosalicylic acid related to endoscopic activity in ulcerative colitis patients with mesalamine"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6539-5002","authenticated-orcid":false,"given":"Tomohiro","family":"Fukuda","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Keio University School of Medicine  Tokyo 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