{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T14:04:10Z","timestamp":1775657050928,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cohort Research Center","award":["KMU-TC108B07"],"award-info":[{"award-number":["KMU-TC108B07"]}]},{"name":"aohsiung Medical University Research Center Grant Center for Liquid Biopsy","award":["KMU-TC108B06"],"award-info":[{"award-number":["KMU-TC108B06"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The serial serologic changes of hepatitis D virus (HDV) infection among chronic hepatitis B virus (HBV) infected patients who received oral nucleotide\/nucleoside analogues are elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum anti\u2010HDV and HDV RNA among chronic hepatitis B (CHB) patients were tested at the time of initiating anti\u2010HBV therapy and subsequently during the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The seropositive rate of anti\u2010HDV and HDV RNA among 2850 CHB patients, was 2.7% and 0.9%, respectively. Factors associated with anti\u2010HDV seropositivity were platelet counts (odds ratio [OR]\/95% confidence intervals [CI]: 0.995\/0.992\u20130.999; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006), HBV DNA levels (OR\/CI: 0.81\/0.70\u20130.94; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005), and hepatitis B e\u2010antigen (HBeAg) seropositivity (OR\/CI: 0.22\/0.05\u20130.95; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). The only factor associated with HDV RNA positivity among anti\u2010HDV seropositive patients was age (OR\/CI: 0.95\/0.90\u20131.00; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). The spontaneous clearance rate of serum anti\u2010HDV antibody was 3.0 per 100 person\u2010years with a median follow\u2010up period of 3.5\u00a0years (range 2\u201312\u00a0years), whereas the seroclearance rate of HDV RNA was 4.3 per 100 person\u2010years among anti\u2010HDV seropositive patients after a median follow\u2010up period of 6.0\u00a0years (range 2\u201311\u00a0years). A baseline anti\u2010HDV titer\u00a0&lt;\u00a00.5 cut\u2010off index was the only factor predictive of anti\u2010HDV seroclearance (hazard ratio [HR]\/CI: 30.11\/3.73\u2013242.85; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HDV infection was not common among patients treated for HBV in Taiwan. Seroclearance of anti\u2010HDV and HDV RNA did occur over time, albeit the chance is rare.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15061","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T22:00:44Z","timestamp":1586037644000},"page":"1886-1892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Serial serologic changes of hepatitis D virus in chronic hepatitis B patients receiving nucleos(t)ides analogues therapy"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-130X","authenticated-orcid":false,"given":"Tyng\u2010Yuan","family":"Jang","sequence":"first","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine Pingtung Hospital, Ministry of Health and Welfare  Pingtung 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