{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:14:36Z","timestamp":1789470876865,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T00:00:00Z","timestamp":1588550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>There are sparse data on the epidemiology of fatty liver in the elderly Asian population. We evaluated for predictors of fatty liver and high risk of advanced fibrosis in a community\u2010based elderly population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1091 participants (mean age was 74.6\u00a0\u00b1\u00a06.3\u00a0years) were enrolled from 2017 to 2018. Subjects with age younger than 65\u00a0years, alcoholism, and history of hepatitis B and hepatitis C were excluded. Fatty liver was diagnosed with abdominal ultrasound by using ultrasonographic fatty liver indicator, a semi\u2010quantitative measurement grading the severity (normal, mild, and moderate\u2010to\u2010severe). Fibrosis\u20104 score was used for the prediction of the high risk of advanced fibrosis. Using a multivariable logistic regression model, we identified predictors of fatty liver and high risk of advanced fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this ambulatory elderly Asian population, the prevalence of fatty liver is 41.9% and of high risk of advanced fibrosis is 12.3%. The prevalence of fatty liver decreases (44.5% to 31.8%), and the high risk of advanced fibrosis increases (3.9% to 27.0%) with aging significantly (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Metabolic syndrome is a risk factor for fatty liver (odds ratio [OR], 3.19; 95% CI, 2.41\u20134.22) but not for high risk of advanced fibrosis (OR, 0.67; 95% CI, 0.41\u20131.08). Hypertriglyceridemia decreases the risk for high risk of advanced fibrosis (OR, 0.53; 95% CI, 0.33\u20130.87).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fatty liver is prevalent in the ambulatory elderly Asian population, affecting over 40% of this population. Age is a risk factor for high risk of advanced fibrosis, with the disease likely progressing from a steatotic to a fibrotic picture with age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15073","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T03:18:16Z","timestamp":1587784696000},"page":"1636-1643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Metabolic profiles and fibrosis of nonalcoholic fatty liver disease in the elderly: A community\u2010based study"],"prefix":"10.1111","volume":"35","author":[{"given":"Tsung\u2010Po","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Community and Family Medicine China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Yuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine China Medical University Hospital  Taichung Taiwan"},{"name":"Department of Social Medicine and Family Medicine, College of Medicine China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo\u2010Chin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Family Medicine National Taiwan University Hospital Bei\u2010Hu Branch  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-2238","authenticated-orcid":false,"given":"Kuen\u2010Cheh","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine National Taiwan University Hospital Bei\u2010Hu Branch  Taipei Taiwan"},{"name":"Community and Geriatric Medicine Research Center National Taiwan University Hospital  Bei\u2010Hu Branch Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.04058.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2005.06.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000176"},{"key":"e_1_2_6_5_1","first-page":"501","article-title":"Relationship between obesity, metabolic syndrome, and nonalcoholic fatty liver disease in the elderly agricultural and fishing population of Taiwan","volume":"9","author":"Shen HC","year":"2014","journal-title":"Clin. 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