{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:10:10Z","timestamp":1787314210793,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Pediatric Crohn's disease (CD) has been shown to have a high recurrence rate following surgical resection. Risk factors for postoperative CD recurrence in children are not well known. The aim of this study was to identify factors influencing postoperative recurrence in pediatric CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pediatric CD patients who underwent surgical resection with primary anastomosis with a minimum follow up of 2\u00a0years were identified from databases at the Royal London Hospital and Massachusetts General Hospital. Patients were subdivided into a recurrence group defined by clinical, endoscopic, histological, radiological and\/or surgical outcomes, and a nonrecurrence group. Patient demographics, initial gastroscopy and colonoscopy findings, Paris classification, and preoperative and postoperative pharmacotherapy were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010six children who underwent an ileal or ileocolonic resection with primary anastomosis were identified. Fifty\u2010seven children had postoperative recurrence. Recurrence was associated with abnormal initial gastroscopy findings (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0077), ileocolonic disease location (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.03), and perianal disease involvement (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.04).\n                    <\/jats:p>\n                    <jats:p>\n                      Patients with abnormal initial gastroscopy had higher rates of relapse (hazard ratio 3.42, 95% confidence interval [CI] [1.86\u20136.30],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001). Multivariate analysis demonstrated that abnormal diagnostic gastroscopy histology was a significant independent predictor of postoperative recurrence in this cohort (odds ratio 1.33, 95% CI [1.04\u20131.70],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.024). The most common histological abnormality was non\u2010\n                      <jats:italic>Helicobacter<\/jats:italic>\n                      gastritis, found in 29\/46 (63%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This dual\u2010center study has shown that the presence of upper gastrointestinal tract inflammation, especially non\u2010\n                      <jats:italic>Helicobacter<\/jats:italic>\n                      gastritis, at the time of diagnosis, is associated with an increased risk of postoperative recurrence in pediatric CD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.15080","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T09:48:58Z","timestamp":1588067338000},"page":"2074-2079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Histology at diagnostic gastroscopy predicts outcome after intestinal resection in pediatric Crohn's disease"],"prefix":"10.1111","volume":"35","author":[{"given":"Zien Vanessa","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Paediatrics Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiranmai","family":"Kosana","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Savarino","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1519-6435","authenticated-orcid":false,"given":"Nicholas","family":"Croft","sequence":"additional","affiliation":[{"name":"Department of Neurogastroenterology Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhia","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3295-1575","authenticated-orcid":false,"given":"Edward","family":"Giles","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Monash University, Centre for Innate Immunity and Infectious Disease, Hudson Institute for Medical Research  Melbourne Victoria 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