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From February 2018 to December 2019, 232 subjects were randomly assigned (1:1 ratio) to receive oral lansoprazole, Takepron OD 30\u00a0mg, once daily before breakfast or oral dexlansoprazole, Dexilant 60\u00a0mg, once daily before breakfast for 8\u00a0weeks. The primary end\u2010point is to compare the symptoms response rate after an 8\u2010week PPI therapy between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 232 study subjects enrolling in this study. After the 8\u2010week PPI therapy, dexlansoprazole\u2010treated group had a significantly higher response rate than lansoprazole\u2010treated group in cough (76.5% <jats:italic>vs<\/jats:italic> 38.0%) and globus (69.7% <jats:italic>vs<\/jats:italic> 30.8%) (<jats:italic>P<\/jats:italic> all\u00a0&lt;\u00a00.05 by intention\u2010to\u2010treat). Multivariate logistic regression analysis showed that the use of dexlansoprazole, presence of dyslipidemia, and typical GERD symptoms (acid reflux and heartburn) were predictors for symptom response for cough; the use of dexlansoprazole and presence of erosive esophagitis were predictors for symptom response for globus (<jats:italic>P<\/jats:italic> all\u00a0&lt;\u00a00.05). No predictor for therapy response to hoarseness was noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a higher response rate for cough and globus symptoms in patients with atypical GERD after the 8\u2010week PPI therapy with dexlansoprazole rather than lansoprazole.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15093","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T20:33:13Z","timestamp":1589401993000},"page":"2096-2102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of the efficiency of two different proton pump inhibitor formula in treatment of patients with atypical gastroesophageal reflux disease: a prospective randomized study"],"prefix":"10.1111","volume":"35","author":[{"given":"Xi\u2010Hsuan","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Medicine, School of Medicine National Yang\u2010Ming 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