{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:52:08Z","timestamp":1792039928700,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Serrated lesions (SLs) have attracted attention as precursors of colorectal cancer (CRC). However, their prevalence, risk factors, and clinical significance have not been satisfactorily elucidated. This study used high\u2010quality colonoscopy data to determine the prevalence of SLs and to identify their risk factors and relationship with synchronous advanced colorectal neoplasia (ACN) in asymptomatic screened individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included data for 5218 individuals who underwent first\u2010time screening colonoscopy by highly experienced endoscopists. The relationships between baseline characteristics and the presence of SLs and those between the presence of SLs and synchronous ACN were assessed using the chi\u2010squared test and multivariate logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportions of individuals with SLs and right\u2010sided SLs were 23.3% and 7.6%, respectively. Age, sex, family history of CRC, smoking, and body mass index were significantly related with the presence of SLs, and current smoking was most strongly associated with SLs (adjusted odds ratio [aOR] 2.6, 95% confidence interval [CI] 2.1\u20133.2). The aOR (95% CI) of the presence of SLs, SLs sized \u2265\u00a010\u00a0mm, and right\u2010sided SLs\u00a0\u2265\u00a05\u00a0mm for synchronous ACN was 1.4 (1.1\u20131.9), 3.5 (1.3\u20139.6), and 1.9 (1.0\u20133.8), respectively. The presence of left\u2010sided SLs\u00a0\u2265\u00a010\u00a0mm (without right\u2010sided SLs) was also significantly associated with ACN (aOR 8.1, 95% CI 2.0\u201333.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The relatively high prevalence of SLs and risk factors in screened individuals were elucidated and the significant relationship between SLs, particularly SLs\u00a0\u2265\u00a010\u00a0mm and right\u2010sided SLs\u00a0\u2265\u00a05\u00a0mm, and synchronous ACN was confirmed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15116","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T09:45:04Z","timestamp":1590140704000},"page":"1938-1944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of serrated lesions, risk factors, and their association with synchronous advanced colorectal neoplasia in asymptomatic screened 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