{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:34:09Z","timestamp":1785296049592,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Although oral mesalamine is the first\u2010choice drug for treating mild\u2010to\u2010moderate ulcerative colitis (UC), some patients show symptoms of intolerance, including exacerbation of diarrhea and abdominal pain. The present study clarified the current state and clinical courses of patients with mesalamine intolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who were diagnosed with UC and administered oral mesalamine at eight hospitals in Japan with a follow\u2010up period exceeding 1\u00a0year were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010seven (11%) of 633 patients showed intolerance to at least one formulation of oral mesalamine. The frequency of mesalamine intolerance has increased in recent years, rising from 5.3% in 2007\u20132010 to 9.1% in 2011\u20132013 and 16.2% in 2014\u20132016. The most common complications were the exacerbation of diarrhea (<jats:italic>n<\/jats:italic>\u00a0=\u00a029), a fever (<jats:italic>n<\/jats:italic>\u00a0=\u00a025), and abdominal pain (<jats:italic>n<\/jats:italic>\u00a0=\u00a022). Readministration of mesalamine\/sulfasalazine was attempted in 43 patients, mostly with other types of formulation of mesalamine, and more than half of these patients proved to be tolerant. The risk factors for mesalamine intolerance were female gender (odds ratio [OR]\u00a0=\u00a01.83; 95% confidence interval [CI], 1.08\u20133.12), age\u00a0&lt;\u00a060\u00a0years old (OR\u00a0=\u00a02.82; CI, 1.19\u20138.33), and pancolitis (OR\u00a0=\u00a02.09; 95% CI, 1.23\u20133.60). There were no significant differences in the use of anti\u2010tumor necrosis factor\u2010\u03b1 agents, colectomy, or steroid\u2010free remission at the last visit between patients with and without mesalamine intolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mesalamine intolerance is not rare, and its frequency has been increasing recently. The prognosis of patients with mesalamine intolerance did not differ significantly from that of those without intolerance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15138","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T15:50:03Z","timestamp":1591890603000},"page":"137-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Multicenter survey on mesalamine intolerance in patients with ulcerative colitis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-6930","authenticated-orcid":false,"given":"Sakiko","family":"Hiraoka","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University Okayama 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