{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:18:58Z","timestamp":1782602338559,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Plummer\u2013Vinson syndrome (PVS) comprises triad of iron deficiency anemia, dysphagia, and post\u2010cricoid esophageal web. PVS is rare nowadays due to improved nutritional status. However, we encountered patients with PVS regularly at our center. Data regarding PVS are limited; hence, we aimed to study the clinical features, treatment outcomes, and development of complications in patients with PVS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was conducted over a 10\u2010year period (January 2008 to January 2018) in a medical college setting. All adults with dysphagia, anemia, and post\u2010cricoid web or those with iron deficiency anemia and post\u2010cricoids web were included in the study. Patients were treated with iron supplementation and Savary\u2013Gilliard bougie dilation of the web. Patients were followed\u2010up for the recurrence of dysphagia and development of complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 153 patients exhibited esophageal web, of which 132 (86.27%) patients had concomitant PVS and 21 (13.7%) patients did not. The mean age was 43.50\u00a0years (range 16\u201376) and 113 (85.6%) were women. Single session of Savary\u2013Gilliard bougie dilation was successful in 90.7% of patients in relieving dysphagia and 9.3% developed recurrence, requiring repeated dilations. Four patients had concomitant squamous cell carcinoma of esophagus along with PVS and two developed upper gastrointestinal malignancy during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Plummer\u2013Vinson syndrome is predominantly seen in middle aged women and present with symptoms of iron deficiency anemia and early grade dysphagia. Single session of Savary\u2013Gilliard bougie dilation was successful in majority of patients in relieving dysphagia. Overall risk of developing upper gastrointestinal malignancy was 4.5%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15139","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T10:25:28Z","timestamp":1591871128000},"page":"181-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Plummer\u2013Vinson syndrome: A decade's experience of 132 cases from a single center"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9238-7657","authenticated-orcid":false,"given":"Mallikarjun","family":"Patil","sequence":"first","affiliation":[{"name":"Department of Gastroenterology St. John's Medical College Hospital  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renuka","family":"Malipatel","sequence":"additional","affiliation":[{"name":"Department of Pathology St. John's Medical College Hospital  Bangalore 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