{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:52:54Z","timestamp":1790481174250,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T00:00:00Z","timestamp":1593907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is associated with metabolic syndrome. Worryingly, it has been increasingly reported among nonobese patients. This study aims to analyse patient characteristics of biopsy\u2010proven NAFLD in an Asian cohort and explore differences stratified by body mass index (BMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical, laboratory, and histological data were collected from 263 adults with biopsy\u2010proven NAFLD. Patients with and without obesity (BMI cut\u2010off 25) were compared. The ability to predict advanced liver fibrosis with three non\u2010invasive scores, the NAFLD Fibrosis score (NFS), Fibrosis\u20104 (FIB4), and the aspartate aminotransferase to platelet ratio index (APRI), was compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Obese subjects had a lower mean age (49.5\u00a0\u00b1\u00a012.5 <jats:italic>vs<\/jats:italic> 54.0\u00a0\u00b1\u00a012.9\u00a0years, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.017), a higher prevalence of diabetes (52.4% <jats:italic>vs<\/jats:italic> 36.8%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.037), and a higher waist circumference (113.9\u00a0\u00b1\u00a016.0\u00a0cm <jats:italic>vs<\/jats:italic> 87.0\u00a0\u00b1\u00a018.4\u00a0cm, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.022). The prevalence of dyslipidaemia (68.0% <jats:italic>vs<\/jats:italic> 61.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.353) and hypertension (61.7% <jats:italic>vs<\/jats:italic> 49.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.190) was comparable between the two groups. The distribution of non\u2010alcoholic steatohepatitis (NASH) (63.1% versus 61.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.710) and advanced fibrosis (31.6% versus 26.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.447) were also similar in both groups. All three non\u2010invasive scores (NFS, FIB4, and APRI) performed poorly in predicting advanced fibrosis in nonobese patients with NAFLD. The FIB4 was the most accurate non\u2010invasive score in predicting advanced fibrosis in the obese group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Obese and nonobese patients are equally at risk of NASH and advanced fibrosis. While the FIB4 is the most accurate non\u2010invasive score in predicting advanced fibrosis among obese individuals, further research is warranted to develop a nonobese specific score to correctly identify nonobese NAFLD patients with advanced fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15154","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T03:35:22Z","timestamp":1592537722000},"page":"257-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical profile of non\u2010alcoholic fatty liver disease in nonobese patients"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-7844","authenticated-orcid":false,"given":"Johnathan Huey Ming","family":"Lum","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  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Cheng","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore"},{"name":"Medicine Academic Clinical Program Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason Pik Eu","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore"},{"name":"Medicine Academic Clinical Program Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Boon Bee","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore"},{"name":"Medicine Academic Clinical Program Duke\u2010NUS Medical School  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