{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:56:33Z","timestamp":1775487393619,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T00:00:00Z","timestamp":1598140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Short stature is a common extraintestinal manifestation of celiac disease (CeD). We conducted a systematic review and meta\u2010analysis to assess the global prevalence of CeD in patients presenting with short stature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched Medline and EMBASE databases for the keywords \u201cceliac disease, coeliac disease, anti\u2010gliadin, tissue transglutaminase antibody, anti\u2010endomysial antibody, short stature and growth retardation.\u201d All the studies published from January 1991 to May 2020 were included. Patients without any prior evaluation for short stature were classified as all\u2010cause short stature, while prior evaluated patients, where no cause was found for short stature, were classified as idiopathic short stature. The diagnosis of CeD was based on the European Society for Paediatric Gastroenterology, Hepatology and Nutrition guidelines. A random\u2010effects model was used to pool the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen studies screening 3759 patients (1582 with all\u2010cause short stature and 2177 with idiopathic short stature) were included. The pooled seroprevalence of CeD based on positive anti\u2010tissue transglutaminase antibody and anti\u2010endomysial antibody was 11.2% (95% CI 4.0\u201321.2%; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a086%) and 9.7% (95% CI 2.7\u201320.2%; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a095%) for all\u2010cause and idiopathic short stature, respectively. Similarly, pooled prevalence of biopsy\u2010confirmed CeD was 7.4% (95% CI 4.7\u201310.6%; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a076%) and 11.6% (95% CI 4.1\u201322.2%; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a097%), for all\u2010cause and idiopathic short stature, respectively. There was an overall severe risk of selection bias and significant heterogeneity in the pooled results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Approximately one in 14 patients with all\u2010cause short stature and one in nine patients with idiopathic short stature had biopsy\u2010confirmed CeD. Therefore, evaluation for CeD may be prudent in all patients with short stature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15167","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T01:53:58Z","timestamp":1593827638000},"page":"44-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prevalence of celiac disease in patients with short stature: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-1071","authenticated-orcid":false,"given":"Achintya D","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic  Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashant","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naba","family":"Farooqui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Human nutrition All India Institute of Medical Sciences  Delhi New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor","family":"Strand","sequence":"additional","affiliation":[{"name":"Department of Global public health Innlandet Hospital Trust  Lillehammer Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5474-9709","authenticated-orcid":false,"given":"Vineet","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Human nutrition All India Institute of Medical Sciences  Delhi New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-2194","authenticated-orcid":false,"given":"Govind K","family":"Makharia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Human nutrition All India Institute of Medical Sciences  Delhi New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301346"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.037"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000450393.23156.59"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31796-8"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10060755"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2017.04.008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-014-1609-y"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502901"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001420"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00056"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181f1dd66"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000064771"},{"key":"e_1_2_5_14_1","first-page":"248","article-title":"Effects of age of diagnosis and dietary compliance on growth parameters of patients with celiac disease","volume":"116","author":"Comba A","year":"2018","journal-title":"Arch. 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