{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:45:23Z","timestamp":1792226723254,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The proportional increase of corrected QT interval (QTc) along end\u2010stage liver disease (ESLD) severity may lead to inconsistent outcome reporting if based on conventional threshold of prolonged QTc. We investigated the comprehensive QTc distribution among ESLD patients and assessed the association between QTc\u00a0&gt;\u00a0500\u00a0ms, a criterion for diagnosing severe long\u2010QT syndrome, and the 30\u2010day major adverse cardiovascular event (MACE) after liver transplantation (LT) and identified the risk factors for developing QTc\u00a0&gt;\u00a0500\u00a0ms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected prospectively from the Asan LT Registry between 2011 and 2018, and outcomes were retrospectively reviewed. Multivariable analysis and propensity score\u2010weighted adjusted odds ratios (ORs) were calculated. Thirty\u2010day MACEs were defined as the composite of cardiovascular mortality, arrhythmias, myocardial infarction, pulmonary thromboembolism, and\/or stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2579 patients, 194 (7.5%) had QTc\u00a0&gt;\u00a0500\u00a0ms (QTc500_Group), and 1105 (42.8%) had prolonged QTc (QTcP_Group), defined as QTc\u00a0&gt;\u00a0470\u00a0ms for women and &gt;450\u00a0ms for men. The 30\u2010day MACE occurred in 336 (13%) patients. QTc500_Group showed higher 30\u2010day MACE than did those without (20.1% <jats:italic>vs<\/jats:italic> 12.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), with corresponding adjusted OR of 1.24 (95% CI: 1.06\u20131.46, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007). However, QTcP_Group showed comparable 30\u2010day MACE (13.3% <jats:italic>vs<\/jats:italic> 12.8% without prolonged QTc, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.764). Significant risk factors for QTc\u00a0&gt;\u00a0500\u00a0ms development were advanced liver disease, female sex, hypokalemia, hypocalcemia, high left ventricular end\u2010diastolic volume, and tachycardia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results revealed that, among ESLD patients, a novel threshold of QTc\u00a0&gt;\u00a0500\u00a0ms was associated with post\u2010LT 30\u2010day MACE but not with conventional threshold, indicating that a longer QTc threshold should be considered for this unique patient population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15179","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T10:14:46Z","timestamp":1594635286000},"page":"758-766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Markedly prolonged QTc interval in end\u2010stage liver disease and risk of 30\u2010day cardiovascular event after liver transplant"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6643-9177","authenticated-orcid":false,"given":"Kyoung\u2010Sun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7788-9555","authenticated-orcid":false,"given":"Hye\u2010Mee","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeo\u2010Woon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Eunpyeong St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010Hyun","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, CHA Bundang Medical Center CHA University  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Jin","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bomi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u2010Gu","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Gol","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyu\u2010Sam","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2018.71.2.85"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.11.86"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.067"},{"key":"e_1_2_5_5_1","first-page":"673","article-title":"Incidence of and risk assessment for adverse cardiovascular outcomes following liver transplantation: a systematic review","volume":"16","author":"Konerman M","year":"2016","journal-title":"Am. 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