{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:03:01Z","timestamp":1785366181971,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Endoscopic post\u2010papillectomy bleeding occurs in 3% to 20% of the cases, and delayed bleeding is also problematic. However, there is no consensus on how to reduce delayed post\u2010papillectomy bleeding. The aim of this study was to evaluate the efficacy of prophylactic argon plasma coagulation (APC) to minimize delayed bleeding and reduce the persistence of residual tumors after endoscopic papillectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective pilot study of patients with benign ampullary tumors, the prophylactic APC group underwent APC at the resection margin following a conventional snaring papillectomy. Then, 24\u00a0h later after the papillectomy, all patients underwent a follow\u2010up duodenoscopy to identify post\u2010papillectomy bleeding and were followed up until 12\u00a0months. The main outcomes were the delayed (\u226524\u00a0h) post\u2010papillectomy bleeding rate and the tumor persistence rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The delayed post\u2010papillectomy bleeding rate was 30.8% (8\/26) in the prophylactic APC group and 21.4% (6\/28) in the non\u2010APC group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.434). The post\u2010procedure pancreatitis rates were 23.1% (6\/26) and 35.7% (10\/28), respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.310). The rate of tumor persistence did not differ between the two groups at 1\u00a0month (12.5% <jats:italic>vs<\/jats:italic> 7.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.656), 3\u00a0months (4.2% <jats:italic>vs<\/jats:italic> 3.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.00), 6\u00a0months (8.3% <jats:italic>vs<\/jats:italic> 3.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.595), and 12\u00a0months (0% <jats:italic>vs<\/jats:italic> 3.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.00). There were no procedure\u2010related mortalities or serious complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prophylactic APC may not be effective in reducing delayed post\u2010papillectomy bleeding or remnant tumor ablation immediately after conventional papillectomy (Clinical trial registration\u2014<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/cris.nih.go.kr\">cris.nih.go.kr<\/jats:ext-link>; KCT0001955).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15186","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T09:45:53Z","timestamp":1594979153000},"page":"467-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Can prophylactic argon plasma coagulation reduce delayed post\u2010papillectomy bleeding? A prospective multicenter trial"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3003-7667","authenticated-orcid":false,"given":"Jae Kook","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine College of Medicine, Soonchunhyang University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5632-7091","authenticated-orcid":false,"given":"Jong Jin","family":"Hyun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University Ansan Hospital  Ansan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3545-9183","authenticated-orcid":false,"given":"Tae Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine College of Medicine, Soonchunhyang University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine Dankook University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Nah","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine College of Medicine, Soonchunhyang University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Wan","family":"Choe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University Ansan Hospital  Ansan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Inha University School of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Il","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine CHA Bundang Medical Center, CHA University  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6178-8338","authenticated-orcid":false,"given":"Seok","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Inha University School of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Ja","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine Dankook University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3946-9944","authenticated-orcid":false,"given":"Jong 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