{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:52:48Z","timestamp":1793289168183,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Remimazolam tosilate (RT) is a new short\u2010acting GABA(A) receptor agonist, having potential to be an effective option for procedural sedation. Here, we aimed to compare the efficacy and safety of RT with propofol in patients undergoing upper gastrointestinal endoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This positive\u2010controlled, non\u2010inferiority, phase III trial recruited patients at 17 centers, between September 2017 and November 2017. A total of 384 patients scheduled to undergo upper gastrointestinal endoscopy were randomly assigned to receive RT or propofol. Primary endpoint was the success rate of sedation. Adverse events (AEs) were recorded to evaluate safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The success rate of sedation in the RT group was non\u2010inferior to that in the propofol group (97.34%\n                      <jats:italic>vs<\/jats:italic>\n                      100.00%; difference in rate \u22122.66%, 95% CI \u22124.96 to \u22120.36, meeting criteria for non\u2010inferiority). Patients in the RT group had longer time to adequate sedation (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) but shorter time to fully alert (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) than that in the propofol group. The incidences of hypotension (13.04%\n                      <jats:italic>vs<\/jats:italic>\n                      42.86%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), treatment\u2010related hypotension (0.54%\n                      <jats:italic>vs<\/jats:italic>\n                      5.82%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), and respiratory depression (1.09%\n                      <jats:italic>vs<\/jats:italic>\n                      6.88%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0064) were significantly lower in the RT group. AEs were reported in 74 (39.15%) patients in the RT group and 114 (60.32%) patients in the propofol group, with significant difference (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This trial established non\u2010inferior sedation success rate of RT compared with propofol. RT allows faster recovery from sedation compared with propofol. The safety profile is favorable and appears to be superior to propofol, indicating that it was feasible and well tolerated for patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.15188","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T05:50:38Z","timestamp":1594965038000},"page":"474-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":237,"title":["Remimazolam tosilate in upper gastrointestinal endoscopy: A multicenter, randomized, non\u2010inferiority, phase III trial"],"prefix":"10.1111","volume":"36","author":[{"given":"Shao\u2010Hui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Chinese Academy of Medical College and Peking Union Medical College Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tang\u2010Mi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Chinese Academy of Medical College and Peking Union Medical College Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Chinese Academy of Medical College and Peking Union Medical College Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Bai","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Research Center Chinese Academy of Medical College and Peking Union Medical College Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu\u2010Xiong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing TongRen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Guang","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Nanjing First Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ju","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Yijishan Hospital of Wannan Medical College  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Hai","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Hospital of Soochow University  Suzhou 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Hao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai\u2010Lin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Tongji Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010Kui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Sichuan Provincial People's Hospital  Chengdu 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