{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T12:00:06Z","timestamp":1771848006727,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["IN\u2010US\u2010334\u20104309"],"award-info":[{"award-number":["IN\u2010US\u2010334\u20104309"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Globally, China has the highest chronic hepatitis C (CHC) burden, but its real\u2010world direct\u2010acting antiviral (DAA) data are limited. Our aim is to investigate the real\u2010world outcome of China Food and Drug Administration\u2010approved DAA therapies across mainland China including those with genotype (GT) 3.<\/jats:p><\/jats:sec>Methods<\/jats:title>The REAL\u2010C is a multinational real\u2010world interferon\u2010free DAA\u2010treated CHC registry of several mainland China and other Asian centers. We evaluated the sustained virological response rate 12\u00a0weeks after end of treatment (SVR12), adverse events, and treatment effect on liver function and fibrosis (fibrosis\u20104 index).<\/jats:p><\/jats:sec>Results<\/jats:title>We analyzed 859 DAA\u2010treated CHC patients (6\/1\/2017\u20135\/30\/2019) from 12 mainland China centers (three municipalities and nine provinces): median age 52, 49.9% male, 33.1% cirrhosis, 95% treatment na\u00efve, and 2.5% HBsAg+<\/jats:sup>. The most common GT was GT1b (523, 62.2%), followed by GT2a (156, 18.5%), GT3b (74, 8.8%), GT3a (41, 4.9%), and GT6 (37, 4.4%). SVR12 rates were 98.0% overall (95% confidence interval 96.9\u201398.8%), 98.1% for GT1b, 96.8% GT2a, 100% GT3a, 97.3% GT3b, and 100% GT6. Baseline cirrhosis and male sex but not prior treatment history, renal dysfunction, age, and GTs were associated with SVR12. For both cirrhotic and non\u2010cirrhotic patients, there were significant improvement in liver function tests, alpha fetoprotein, and fibrosis\u20104 index with SVR12. Serious adverse events were rare (1.1%) with only nine patients discontinuing therapy prematurely and anemia being the most common adverse event (13.1%, mostly with ribavirin).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In real\u2010world Chinese patients with diverse GTs, Chinese Food and Drug Administration\u2010approved interferon\u2010free DAAs were well tolerated, provided high cure rates (98.0% overall) including GT3a\/3b, and led to improvement of liver function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15192","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T19:10:01Z","timestamp":1595445001000},"page":"767-774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["High hepatitis C virus cure rates with approved interferon\u2010free direct\u2010acting antivirals among diverse mainland Chinese patients including genotypes 3a and 3b"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1463-8035","authenticated-orcid":false,"given":"Fanpu","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Third People's Hospital of Kunming Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5114-9030","authenticated-orcid":false,"given":"Jing","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of 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