{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:46:43Z","timestamp":1784260003265,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Functional dyspepsia (FD) is common in children, and treatment targeted towards the altered pathophysiology can improve outcome. We evaluated FD children for abnormality of gastric accommodation and emptying, psychological stressors (PS), <jats:italic>Helicobacter pylori<\/jats:italic> (HP) infection, and post\u2010infectious FD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Diagnosis of FD was based on ROME III criteria. Clinical evaluation including dyspeptic symptom scoring and assessment for PS was performed. Satiety drink test for gastric accommodation, gastroscopy with biopsy for HP infection, and solid meal gastric emptying were performed. Sixty\u2010seven healthy children were enrolled for assessing PS and satiety drink test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five FD children (33 boys, age 12 [6\u201318] years) with symptoms for 4 (2\u201348) months and dyspeptic score of 5 (1\u201313) were enrolled. PS were more common in FD than in controls (46\/55 <jats:italic>vs<\/jats:italic> 9\/67; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Median satiety drink volume was 360\u00a0mL (180\u20131320\u00a0mL); no patients had satiety drink volume of &lt;\u00a05th centile of healthy children. The frequency (98% <jats:italic>vs<\/jats:italic> 85%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and severity (65 [10\u2013175] <jats:italic>vs<\/jats:italic> 50 [5\u2013130]; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) of postprandial symptoms were higher in FD than in controls. Of the postprandial symptoms, pain (20.3% <jats:italic>vs<\/jats:italic> 0%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.000) was present only in FD. Delayed gastric emptying was present in 6.5%, HP infection in 11%, and post\u2010infectious FD in 13% cases. Etiological factor was identified in 87% children, with 20% having multiple factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abnormality of gastric sensorimotor function is seen in one\u2010fourth of FD cases. HP infection and post\u2010infectious FD are present in 11% and 13% cases, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15193","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T15:29:34Z","timestamp":1595690974000},"page":"680-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Functional dyspepsia in children: A study of pathophysiological factors"],"prefix":"10.1111","volume":"36","author":[{"given":"Upender","family":"Shava","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-4140","authenticated-orcid":false,"given":"Anshu","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Mathias","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narvesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surender Kumar","family":"Yachha","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Gambhir","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5277-4401","authenticated-orcid":false,"given":"Ujjal","family":"Poddar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70246-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmq039"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rgmx.2015.03.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.05.030"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/351086"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2013.809063"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.043"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12205"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.11.031"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.063"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70012-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182296033"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2002.00326.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-017-0794-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13145"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.5.467"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajgsup.2012.2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.12.050"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-015-0566-5"},{"key":"e_1_2_6_21_1","first-page":"S42","article-title":"Prevalence and risk factors of dyspepsia in Thai school children","volume":"95","author":"Phavichitr N","year":"2012","journal-title":"J. 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