{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:55:47Z","timestamp":1792007747894,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>\u039don\u2010alcoholic fatty liver disease (NAFLD) is estimated to be the most common cause of end\u2010stage liver disease in the next years. Vitamin E has shown beneficial effects as a possible \u201cscavenger\u201d of oxidative stress products, which play a major role in pathogenesis of the disease. The purpose of the present meta\u2010analysis is to investigate the effects of vitamin E supplementation in biochemical and histological parameters in adult patients with NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature search was performed in major electronic databases (MEDLINE, CENTRAL, and Embase) up to June 2020 for randomized clinical trials, which examined vitamin E <jats:italic>versus<\/jats:italic> placebo treatment in adults with NAFLD. Changes in liver enzymes were considered as primary outcomes while changes in histological, biochemical, and metabolic parameters as secondary. Quality of evidence was assessed through risk of bias according to the Cochrane risk of bias tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight studies were included in qualitative analysis and seven in quantitative analysis. Vitamin E reduced the values of liver enzymes compared with placebo (\u22127.37\u00a0IU\/L, 95% confidence interval: \u221210.11 to \u22124.64 for alanine aminotransferase, and \u22125.71\u00a0IU\/L, 95% confidence interval: \u22129.49 to \u22121.93 for aspartate aminotransferase). Additionally, vitamin E improved statistically significantly liver pathology in every individual histological parameter as well as low\u2010density lipoprotein cholesterol, fasting blood glucose, and serum leptin values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vitamin E can improve biochemical and histological characteristics of NAFLD patients, especially of non\u2010alcoholic steatohepatitis patients. The results indicate that vitamin E could be a promising choice and be considered as a treatment option in patients with NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15221","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T11:19:25Z","timestamp":1598613565000},"page":"311-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Systematic review with meta\u2010analysis: The effect of vitamin E supplementation in adult patients with non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6130-7127","authenticated-orcid":false,"given":"Andreas","family":"Vadarlis","sequence":"first","affiliation":[{"name":"Laboratory of Hygiene, Social and Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"},{"name":"Department of Gastroenterology and Hepatology General Hospital of Thessaloniki \u201cG. Papanikolaou\u201d  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5164-7435","authenticated-orcid":false,"given":"Christina","family":"Antza","sequence":"additional","affiliation":[{"name":"3<sup>rd<\/sup> Department of Internal Medicine, G. N Papageorgiou Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra Rafailia","family":"Bakaloudi","sequence":"additional","affiliation":[{"name":"Laboratory of Hygiene, Social and Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2184-3296","authenticated-orcid":false,"given":"Ioannis","family":"Doundoulakis","sequence":"additional","affiliation":[{"name":"Laboratory of Hygiene, Social and Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4962-790X","authenticated-orcid":false,"given":"Georgios","family":"Kalopitas","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, 1st Department of Internal Medicine, AHEPA University Hospital, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6943-5091","authenticated-orcid":false,"given":"Myrto","family":"Samara","sequence":"additional","affiliation":[{"name":"Laboratory of Hygiene, Social and Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Dardavessis","sequence":"additional","affiliation":[{"name":"Laboratory of Hygiene, Social and Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theofanis","family":"Maris","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology General Hospital of Thessaloniki \u201cG. 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